Synthesis of nickel dopped chitosan nanoparticles as a novel platform for electrochemical insulin detection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F25%3A63595779" target="_blank" >RIV/70883521:28610/25:63595779 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2590137025000512?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2590137025000512?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biosx.2025.100624" target="_blank" >10.1016/j.biosx.2025.100624</a>

Result language

angličtina

Original language name

Synthesis of nickel dopped chitosan nanoparticles as a novel platform for electrochemical insulin detection

Original language description

Nickel modified chitosan nanoparticles are promising catalysts for the determination of bioanalytes such as insulin, glucose, antibiotics, and ascorbic acid. In this study, we synthesized nickel-loaded chitosan nanoparticles to evaluate their potential as surface modifiers for electrochemical sensors for insulin detection. The nanoparticles were prepared using the ionic gelation of chitosan with tripolyphosphate anions, followed by adsorption of nickel ions via ion-exchange resins and surface chelation. The physicochemical properties of the nanoparticles were characterized by scanning electron microscopy with EDX analysis, transmission electron microscopy, Fourier-transform infrared spectroscopy, and dynamic light scattering. The catalytic activity of nickel modified chitosan nanoparticles towards insulin oxidation was investigated through cyclic voltammetry. The resulting screen-printed carbon electrode modified with nickel-chitosan nanoparticles exhibited exceptional analytical performance, including high sensitivity (0.09 mA μM), a low detection limit (0.02 μM), and a wide dynamic range (300 nM–5 μM). Additionally, the modified screen-printed electrode demonstrated excellent selectivity, enabling accurate insulin determination in the presence of interferences and in real blood serum samples. These findings highlight the potential of nickel-modified chitosan nanoparticles as a surface modification strategy to enhance the performance of electrochemical sensors insulin detection and pave the way for their application in various bioanalytes determination platforms.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biosensors and Bioelectronics: X

ISSN

2590-1370

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

Neuveden

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

nestránkováno

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-105004266081