Identification and analysis of 2,4- and 2,6-toluenediisocyanate (TDI) adducts at the N-terminal valine of globin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F09%3A00007695" target="_blank" >RIV/75010330:_____/09:00007695 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Identification and analysis of 2,4- and 2,6-toluenediisocyanate (TDI) adducts at the N-terminal valine of globin

Original language description

Diisocyanates, reactive compounds used in the production of polyurethanes and potent occupational allergens, readily bind to nucleophilic groups of proteins. The stable adducts formed by the reaction of xenobiotics with blood proteins are increasingly used as exposure indicators.To extend the biomonitoring scope of 2,4- and 2,6-toluenediisocyanate (2,4- and 2,6-TDI), we investigated their adducts at the N-terminal valine of globin.

Czech name

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Czech description

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Type

A - Audiovisual production

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/GA310%2F00%2F0934" target="_blank" >GA310/00/0934: Biological monitoring of the exposure to 2,4-toluene-diisocyanate based on specific adducts with globin</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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