TEM-1 ß-lactamase as a source of resistance to sulbactam in clinical strains of Acinetobacter baumannii

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F13%3A00010121" target="_blank" >RIV/75010330:_____/13:00010121 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/jac/dkt275" target="_blank" >http://dx.doi.org/10.1093/jac/dkt275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jac/dkt275" target="_blank" >10.1093/jac/dkt275</a>

Result language
angličtina
Original language name
TEM-1 ß-lactamase as a source of resistance to sulbactam in clinical strains of Acinetobacter baumannii
Original language description
Sulbactam is well known to have clinically relevant intrinsic activity against Acinetobacter baumannii. Although secondary resistance to this drug has long been reported in acinetobacters, virtually nothing is known about its molecular basis. The aim ofthis study was to test the hypothesis that ß-lactamase TEM-1 is responsible for sulbactam resistance in A. baumannii. The results presented suggest that TEM-1 represents a clinically relevant mechanism of sulbactam resistance in A. baumannii.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
<a href="/en/project/NT14466" target="_blank" >NT14466: Genomic analysis of antibiotic multiresistance in a global epidemic clone of Acinetobacter baumannii.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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