Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F14%3A00010721" target="_blank" >RIV/75010330:_____/14:00010721 - isvavai.cz</a>
Result on the web
<a href="http://www.bmj.com/content/348/bmj.g3656" target="_blank" >http://www.bmj.com/content/348/bmj.g3656</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/bmj.g3656" target="_blank" >10.1136/bmj.g3656</a>

Result language
angličtina
Original language name
Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
Original language description
To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH) D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences. Design Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US. Setting General population. Participants 26 018 men and women aged 50-79 years. Main outcome measures All-cause, cardiovascular, and cancer mortality. Results 25(OH) Dconcentrations varied strongly by season (higher in summer), country (higher in US and northern Europe) and sex (higher in men), but no consistent trend with age was observed. During follow-up, 6695 study participants died, among whom 2624 died of cardiovascular diseases and 2227 died of cancer. For each cohort and analysis, 25(OH) D quintiles were defined with cohort and subgroup specific cut-off values. Comparing bottom versus top quintiles resulted in a pooled risk ratio of 1.57 (95%
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FQ - Public health system, social medicine
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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