Ovarian Stem Cell Niche and Follicular Renewal in Mammals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00470504" target="_blank" >RIV/86652036:_____/11:00470504 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ar.21422" target="_blank" >http://dx.doi.org/10.1002/ar.21422</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ar.21422" target="_blank" >10.1002/ar.21422</a>
Alternative languages
Result language
angličtina
Original language name
Ovarian Stem Cell Niche and Follicular Renewal in Mammals
Original language description
Stem cell niche consists of perivascular compartment, which connects the stem cells to the immune and vascular systems. During embryonic period, extragonadal primordial germ cells colonize coelomic epithelium of developing gonads. Subsequently, ovarian stem cells (OSC) produce secondary germ cells under the influence of OSC niche, including immune system-related cells and hormonal signaling. The OSC in fetal and adult human ovaries serve as a source of germ and granulosa cells. Lack of either granulosa or germ cell niche will result in premature ovarian failure in spite of the presence of OSC. During perinatal period, the OSC transdifferentiate into fibroblast-like cells forming the ovarian tunica albuginea resistant to environmental threats. They represent mesenchymal precursors of epithelial OSC during adulthood. The follicular renewal during the prime reproductive period (PRP) ensures that there are fresh eggs available for a healthy progeny. End of PRP is followed by exponentially growing fetal genetic abnormalities. The OSC are present in adult, aging, and postmenopausal ovaries, and differentiate in vitro into new oocytes. During in vitro development of large isolated oocytes reaching 200 mu m in diameter, an ancestral mechanism of premeiotic nurse cells, which operates during oogenesis in developing ovaries from invertebrates to mammalian species, is utilized. In vitro developed eggs could be used for autologous IVF treatment of premature ovarian failure. Such eggs are also capable to produce parthenogenetic embryos like some cultured follicular oocytes. The parthenotes produce embryonic stem cells derived from inner cell mass, and these cells can serve as autologous pluripotent stem cells. Anat Rec, 294: 1284-1306, 2011. (C) 2011 Wiley-Liss, Inc.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
ISSN
1932-8486
e-ISSN
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Volume of the periodical
294
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
22
Pages from-to
1284-1306
UT code for WoS article
000293748400003
EID of the result in the Scopus database
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