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Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F12%3A00470484" target="_blank" >RIV/86652036:_____/12:00470484 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1186/1477-7827-10-97" target="_blank" >http://dx.doi.org/10.1186/1477-7827-10-97</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/1477-7827-10-97" target="_blank" >10.1186/1477-7827-10-97</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

  • Original language description

    The immune system plays an important role in the regulation of tissue homeostasis. Function of distinct tissues during adulthood, including the ovary, requires (1) Renewal from stem cells, (2) Preservation of tissue-specific cells in a proper differentiated state, which differs among distinct tissues, and (3) Regulation of tissue quantity. Such morphostasis can be executed by the tissue control system. Subsequently, the tissues are maintained in a state of differentiation reached during the adaptation by a "stop effect" of resident and self renewing monocyte-derived cells. Alteration of certain tissue differentiation during the critical developmental period causes persistent alteration of that tissue function, including premature ovarian failure (POF) and primary amenorrhea. In fetal and adult human ovaries the ovarian surface epithelium cells called ovarian stem cells (OSC) are bipotent stem cells for the formation of ovarian germ and granulosa cells. Immune system-related cells and molecules accompany asymmetric division of OSC resulting in the emergence of secondary germ cells, symmetric division, and migration of secondary germ cells, formation of new granulosa cells and fetal and adult primordial follicles (follicular renewal), and selection and growth of primary/preantral, and dominant follicles. The secondary germ cells also develop in the OSC cultures derived from POF and aging ovaries. Such germ cells are capable of differentiating in vitro into functional oocytes. The observations indicating involvement of immunoregulation in physiological neo-oogenesis and follicular renewal from OSC during the fetal and prime reproductive periods are reviewed as well as immune system and age-independent neo-oogenesis and oocyte maturation in OSC cultures, perimenopausal alteration of homeostasis causing disorders of many tissues, and the first OSC culture clinical trial.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Reproductive Biology and Endocrinology

  • ISSN

    1477-7827

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    Nov 23

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    45

  • Pages from-to

  • UT code for WoS article

    000313963800001

  • EID of the result in the Scopus database