Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00571547" target="_blank" >RIV/86652036:_____/23:00571547 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10464327 RIV/00216208:11110/23:10464327

Result on the web

<a href="https://rupress.org/jcb/article/222/3/e202211044/213873/Mitochondria-on-the-move-Horizontal-mitochondrial" target="_blank" >https://rupress.org/jcb/article/222/3/e202211044/213873/Mitochondria-on-the-move-Horizontal-mitochondrial</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1083/jcb.202211044" target="_blank" >10.1083/jcb.202211044</a>

Result language

angličtina

Original language name

Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

Original language description

Jiri Neuzil and colleagues review the processes and mechanisms that underlie horizontal mitochondrial transfer (HMT) and the metabolic consequences of HMT in cells. Mammalian genes were long thought to be constrained within somatic cells in most cell types. This concept was challenged recently when cellular organelles including mitochondria were shown to move between mammalian cells in culture via cytoplasmic bridges. Recent research in animals indicates transfer of mitochondria in cancer and during lung injury in vivo, with considerable functional consequences. Since these pioneering discoveries, many studies have confirmed horizontal mitochondrial transfer (HMT) in vivo, and its functional characteristics and consequences have been described. Additional support for this phenomenon has come from phylogenetic studies. Apparently, mitochondrial trafficking between cells occurs more frequently than previously thought and contributes to diverse processes including bioenergetic crosstalk and homeostasis, disease treatment and recovery, and development of resistance to cancer therapy. Here we highlight current knowledge of HMT between cells, focusing primarily on in vivo systems, and contend that this process is not only (patho)physiologically relevant, but also can be exploited for the design of novel therapeutic approaches.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cell Biology

ISSN

0021-9525

e-ISSN

1540-8140

Volume of the periodical

222

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

27

Pages from-to

e202211044

UT code for WoS article

000944268100001

EID of the result in the Scopus database

2-s2.0-85148259890