Current therapeutic targets and multifaceted physiological impacts of caffeine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00582877" target="_blank" >RIV/86652036:_____/23:00582877 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ptr.8000" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ptr.8000</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ptr.8000" target="_blank" >10.1002/ptr.8000</a>
Alternative languages
Result language
angličtina
Original language name
Current therapeutic targets and multifaceted physiological impacts of caffeine
Original language description
Caffeine, which shares consubstantial structural similarity with purine adenosine, has been demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the biological functions at physiologically relevant dosages. Accumulating evidence supports caffeine's beneficial effects against different disorders, such as total cardiovascular diseases and type 2 diabetes. Conversely, paradoxical effects are also linked to caffeine ingestion in humans including hypertension-hypotension and tachycardia-bradycardia. These observations suggest the association of caffeine action with its ingested concentration and/or concurrent interaction with preferential molecular targets to direct explicit events in the human body. Thus, a coherent analysis of the functional targets of caffeine, relevant to normal physiology, and disease pathophysiology, is required to understand the pharmacology of caffeine. This review provides a broad overview of the experimentally validated targets of caffeine, particularly those of therapeutic interest, and the impacts of caffeine on organ-specific physiology and pathophysiology. Overall, the available empirical and epidemiological evidence supports the dose-dependent functional activities of caffeine and advocates for further studies to get insights into the caffeine-induced changes under specific conditions, such as asthma, DNA repair, and cancer, in view of its therapeutic applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytotherapy Research
ISSN
0951-418X
e-ISSN
1099-1573
Volume of the periodical
37
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
41
Pages from-to
5558-5598
UT code for WoS article
001059890800001
EID of the result in the Scopus database
2-s2.0-85170287051