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32 (0,101s) •

Projekt

Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases (KJB400040601)

This application proposes to examine efficiency of various conventional and novel antitumor platinum and ruthenium coordination complexes to eject zinc from zinc finger proteins and whether this replacement affects binding affinity of these ...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • AV ČR
Projekt

Deciphering biological role of ZNF644 to edit the activity of G9a/GLP methylation complex (GA19-21696S)

ZNF644 and WIZ, two zinc fingers, interact with G9a/GLP complex and mediate H3K9 methylation, resulting in specific gene repression. Although G9a and GLP have been studied extensively, the interaction between these proteins and other complex...

Human genetics

  • 2019 - 2023
    • •
  • 8 826 tis. Kč
    • •
  • 7 956 tis. Kč
    • •
  • GA ČR
Projekt

The role of Plzf (Promyelocytic leukemia zinc finger) gene in the pathogenesis of cardiovascular and metabolic disturbances in rat models (GAP301/10/0756)

Promyelocytic leukemia zinc finger (Plzf) is a transcription repressor with multiple functions. Recent published results suggest a possible, important, role of Plzf in regulation of blood pressure, first via sodium reabsorption in kidney, an...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 5 980 tis. Kč
    • •
  • 5 980 tis. Kč
    • •
  • GA ČR
Projekt

Targeted mutagenesis in silkworm (GAP305/10/2406)

of this project is to explore the possible application of gene targeting by zinc finger based breaks in germ line DNA via direct injection of mRNAs encoding zinc finger nucleases......

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 6 804 tis. Kč
    • •
  • 6 804 tis. Kč
    • •
  • GA ČR
Projekt

Characterization of MAGE proteins cofactors for E3 ubiquitin ligases? (IAA501630902)

, Nse1 isa putative RING finger E3 ubiquitin ligase, there are two other reports of MAGE proteins interacting with RING-finger proteins. In addition, our structure......

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 893 tis. Kč
    • •
  • 2 893 tis. Kč
    • •
  • AV ČR
Projekt

Abate of Pollutant Emissions (SM/9/14/04)

The project is focused on the emission source finger prints in exposed areas of Prague and Ostravafor the purpose of application of receptor models and BAT/BREF assessments of used technologies.Especial attention is focused on problems of th...

DI - Znečištění a kontrola vzduchu

  • 2004 - 2006
    • •
  • 3 885 tis. Kč
    • •
  • 3 520 tis. Kč
    • •
  • MŽP
Projekt

Predictive Data Modeling for Effective Gene Therapy and Bone Marrow Transplantation (ME10047)

The goal of the project is to create and validate statistical, relational-logic and combined classification models for the prediction of interaction of proteins (mainly zinc-fingers) with DNA, and thus enable to improve the outcomes of gene ...

IN - Informatika

  • 2010 - 2012
    • •
  • 1 334 tis. Kč
    • •
  • 1 334 tis. Kč
    • •
  • MŠMT
Projekt

Applied research and development of new priciples of signal reception and processing by passive search systems. (FF-P2/009)

Research and development of new signal analysing methods with the following aim to achieve a perfect signal analysis and to bring finger printing features to perfection, to eliminate in the system cases of targenting by side lobes of the ant...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2003 - 2005
    • •
  • 90 557 tis. Kč
    • •
  • 40 500 tis. Kč
    • •
  • MPO
Projekt

Biomechanical problems of bones and joints of hand including implants (IAA2071003)

and the replacements of the finger joints. The proposed project concerns computational ofthe implant on the behaviour and the stress state of the respective finger bones......

JM - Inženýrské stavitelství

  • 2000 - 2002
    • •
  • 1 423 tis. Kč
    • •
  • 620 tis. Kč
    • •
  • AV ČR
Projekt

Molecular basis for site-specific read-out of histone H3K4me2 by the Set3 PHD finger (GA15-17670S)

as the Set3 PHD finger domain lacks the key residues forming aromatic cage that is known...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 8 040 tis. Kč
    • •
  • 8 040 tis. Kč
    • •
  • GA ČR
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