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2 433 (0,084s)

Projekt

Identification and role of RNA surveillance and degradation factors in the regulation of gene expression (GA23-07372S)

synthesis by direct mRNA modifications or via tailing of regulatory noncoding RNAs (ncRNAs). In this project we investigate how 3‘ terminal uridylation affects synthesisPosttranscriptional untemplated 3’ prime terminal tai...

Biochemistry and molecular biology

  • 2023 - 2025
  • 11 816 tis. Kč
  • 11 816 tis. Kč
  • GA ČR
Projekt

Study of the regulation of ribosomal RNA synthesis in normal and malignant blood cells. (NC5933)

Investigation of the fuctional link between expression and phosphorylation of nucleolar transcription factors and regulatory mechanism of ribosomal RNA synthesis performed on normal and leukemic blood cells with stimulated or respre...

FD - Onkologie a hematologie

  • 2000 - 2002
  • 5 011 tis. Kč
  • 4 685 tis. Kč
  • MZ
Projekt

Topography of nuclear architecture associated with the RNA synthesis, processing and transport (GA304/96/0879)

9H - 9

  • 1996 - 1996
  • 0 tis. Kč
  • 4 962 tis. Kč
  • GA ČR
Projekt

The role of peptides in the emergence of primordial ribosomes (GA25-15428S)

Ribosome is an efficient catalyst of protein synthesis present in all forms in the primordial soup interacted, yielding diverse condensates primarily composed of RNA that gave rise to specific protein-RNA interactions formi...

Biophysics

  • 2025 - 2027
  • 8 560 tis. Kč
  • 8 389 tis. Kč
  • GA ČR
Projekt

Structural studies of protein-RNA complexes involved in RNA quality control (GA204/08/1212)

are engaged in protein synthesis and other cellular processes. One of the RNA qualityTo control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade...

EB - Genetika a molekulární biologie

  • 2008 - 2010
  • 6 990 tis. Kč
  • 2 490 tis. Kč
  • GA ČR
Projekt

Structural studies of protein-RNA complexes involved in RNA quality control (LA08008)

steps of information transfer. RNA maturation involves extensive processing that has a relatively high error rate. Cells have developed an RNA quality control mechanism which identifies improperly processed RNAs and subseq...

CE - Biochemie

  • 2008 - 2010
  • 1 833 tis. Kč
  • 1 833 tis. Kč
  • MŠMT
Projekt

Dynamics of Spliceosome assembly (IAA5039103)

and fluorescently labelled RNA constructs bearing specific sequences, that are essential, RNA constructs by means of microinjection.......

EA - Morfologické obory a cytologie

  • 2001 - 2005
  • 3 336 tis. Kč
  • 1 708 tis. Kč
  • AV ČR
Projekt

New Generation of Antibacterial Agens (2B06065)

site of bacterial RNA polymerase (RNAP). RNAP is a key cellular enzyme that is required for the synthesis of ribosomal RNA, an essential part of the ribosome the synthesis of new ribosomes in bacteria. The ribosom...

EB - Genetika a molekulární biologie

  • 2006 - 2011
  • 32 712 tis. Kč
  • 28 784 tis. Kč
  • MŠMT
Projekt

Centre for RNA Biology (GBP305/12/G034)

The world of RNA expands from nucleus, where its various forms are synthesized and specifically modified, into cytoplasm, where RNA serves as a template for timely and spatially controllable protein synthesis, back-bone of ...

EB - Genetika a molekulární biologie

  • 2012 - 2018
  • 87 942 tis. Kč
  • 87 942 tis. Kč
  • GA ČR
Projekt

Computational study of RNA multiple junctions localized in functionally important sites of the ribosome (KJB400040901)

The project is focused on study of ribosomal RNA multiple junctions complex molecules composed of RNA motifs/submotifs. These systems consist of non-standard pairs and have specific structure dynamical properties that assert in ...

CE - Biochemie

  • 2009 - 2011
  • 717 tis. Kč
  • 717 tis. Kč
  • AV ČR
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