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1 079 (0,086s) •

Projekt

Combinatorial approach to myelin and/or beta-sheet breakers. Implication for the therapeutic approaches to Alzheiner's and prion diseases (GA203/02/1379)

-intercalator peptide library functionalized with 9-amino acridine and to prepare a peptide part we will examine ability of bis-intercalator peptide library to prevent peptide aggregates. In these...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 840 tis. Kč
    • •
  • 1 327 tis. Kč
    • •
  • GA ČR
Projekt

Non-natural inhibitors of physiologically important protein interaction systems based on synthetic combinatorial libraries (GA203/97/1025)

Combinatorial libraries are new methods for efficient synthesis and screening blocks. The libraries are a potential source of biologically active agents that mimic of the multidisciplinary project is development and preparation of c...

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 711 tis. Kč
    • •
  • 1 776 tis. Kč
    • •
  • GA ČR
Projekt

Design, synthesis, screening and functional study of peptides with high affinity to heavy metals;their presentation on bacterial surface (GA203/98/0650)

on the synthesis of peptides using combinatorial chemistry. This will be done by synthesis and screening of peptide libraries. Parallel approach will be based on computermodeling and study sof peptide metal intera...

CE - Biochemie

  • 1998 - 2000
    • •
  • 1 996 tis. Kč
    • •
  • 1 849 tis. Kč
    • •
  • GA ČR
Projekt

Peptides controlling membrane curvature (LUC25012)

. The main aim of this project is the creation of a peptide library capable of detectingThe project focuses on lipid membrane curvature and peptides that are sensitive Gaussian curvatures. We will use this library ...

Biophysics

  • 2025 - 2027
    • •
  • 4 689 tis. Kč
    • •
  • 4 689 tis. Kč
    • •
  • MŠMT
Projekt

Visual and/or fluorescent molecular recognition of cyclic nucleotides with azo-bridged cyclic peptide libraries (GA203/04/1421)

will synthesizeAzo-Peptide-Macro-Cycles libraries of tetra-, penta- and hexapeptides-compound libra­ries will be used. Therefore, each peptide on the bead can be assayed......

CC - Organická chemie

  • 2004 - 2006
    • •
  • 2 662 tis. Kč
    • •
  • 2 662 tis. Kč
    • •
  • GA ČR
Projekt

The development of biochemical methods detecting HLA class I molecules. (IZ4415)

Development of new biochemical methods for the detection of HLA claas I molecules.Application of complete peptide libraries in analyses of HLA epitopes.Clinical impact on bone transplantation.......

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 3 219 tis. Kč
    • •
  • 2 140 tis. Kč
    • •
  • MZ
Projekt

Expression of tick Ixodes ricinus genes following blood meal and borrelia (IAA6022306)

and humoral innate immune response involving phagocytic hemocytes, antibacterial peptides and lectins. The development of the PCR-Select cDNA libraries to isolate and characterize(s) and immune peptides will be performed a...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 3 699 tis. Kč
    • •
  • 1 404 tis. Kč
    • •
  • AV ČR
Projekt

Synthesis and screening of selective probes for magnetic resonance imaging (GJ17-22834Y)

blocks will be prepared that allow incorporation of metal chelates into peptide chains. Combinatorial synthesis on solid phase will be used to prepare libraries of the chelate. A new approach is proposed for screening of compound <...

CC - Organická chemie

  • 2017 - 2021
    • •
  • 5 331 tis. Kč
    • •
  • 5 331 tis. Kč
    • •
  • GA ČR
Projekt

Solid-phase synthesis of diversely constrained peptidomimetics. (GAP207/12/0473)

critical advantages: 1. Incorporation of fused and bridged peptide backbone constraints of so far unexplored peptide backbone constraints. 3. Access to diversity design and synthesis of targeted libraries for subsequent SA...

CC - Organická chemie

  • 2012 - 2014
    • •
  • 9 375 tis. Kč
    • •
  • 9 175 tis. Kč
    • •
  • GA ČR
Projekt

Design of novel peptidic inhibitors of cysteine and aspartic proteases (GP203/01/D008)

willbe designed de novo using technology of combinatorial peptide libraries. Further, rational design will be performed based on propart "activation" peptides and molecular......

CE - Biochemie

  • 2001 - 2004
    • •
  • 846 tis. Kč
    • •
  • 605 tis. Kč
    • •
  • GA ČR
  • 1 - 10 z 1 079