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58 (0,089s) •

Projekt

Mitochondrial diseases with ocular involvement – study of risk factors and optimization of diagnosis and management strategy (NV16-32341A)

Ocular involvement figures prominently in the phenotypic spectrum of mitochondrial disorders. Leber’s hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA) type 1 represent the two most common non-syndromic hereditary optic neuropathies...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 12 597 tis. Kč
    • •
  • 12 597 tis. Kč
    • •
  • MZ
Projekt

Molecular aspects and biochemical and clinical consequences of maternally inherited mitochondrial disorders (NR8065)

Maternally inherited mitochondrial disorders due to mtDNA mutations represent the hypothesis that beside the level of heteroplasmy of pathogenic mtDNA mutations also the mtDNA haplotype, absolute amount of mtDNA, a...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 4 910 tis. Kč
    • •
  • 4 909 tis. Kč
    • •
  • MZ
Projekt

The role of mitochondrial respiration in tumour initiation and growth A mechanistic study (GC17-01192J)

Cancer cells are so dependent on mitochondrial mtDNA for their growth, that in case of damage to their mtDNA, they acquire mitochondrial genome from host cells. Horizontal transfer of mtDNA is required for tumour formation,...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 860 tis. Kč
    • •
  • 7 860 tis. Kč
    • •
  • GA ČR
Projekt

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

and mortality. OXPHOS biogenesis is under dual genetic control, mitochondrial DNA (mtDNA) and nuclear genome. Subgroup of MD is characterized by mtDNA instability. MtDNA deletions may be caused by mutations in nuclear gene...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Projekt

Genetic analysis of the role of mitochondria in the pathogenesis of metabolic syndrome studied in new rat conplastic strains (GA301/08/0166)

Recently, the potential role of mitochondrial DNA (mtDNA) variants in common and the metabolic syndrome. Preliminary analysis of mtDNA sequence from SHR and Brown Norway (BN (SHRxBN)F1 females with identical nuclear genomes but with...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 6 896 tis. Kč
    • •
  • 6 896 tis. Kč
    • •
  • GA ČR
Projekt

Mitochondrial and nuclear DNA cross-talk and its impact on metabolic phenotype and innate immunity (GA19-10354S)

circular DNA (mtDNA). Human mtDNA exerts considerable sequence variability dividing the population into different mtDNA subpopulations known as haplogroups. Recently, many studies suggested that mtDNA may trigge...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2022
    • •
  • 6 634 tis. Kč
    • •
  • 6 580 tis. Kč
    • •
  • GA ČR
Projekt

Properties of horizontal mitochondrial transfer in cancer (GJ18-24753Y)

in the form of mitochondrial DNA (mtDNA). Cell type mtDNA heteroplasmy was reported before cells. Cellular mtDNA heterogeneity and transport are potentially connected in both for therapy. Our mouse strains with specific

Cell biology

  • 2018 - 2022
    • •
  • 5 898 tis. Kč
    • •
  • 5 898 tis. Kč
    • •
  • GA ČR
Projekt

Mitochondiral diseases caused by depletion and mutation of mitochondrial DNA (ME 226)

are problematic due to complicated genetics of the mitochondrial DNA (mtDNA) genes. The aim mtDNA defects, namely depletion of mtDNA and mutations in tRNA, cytochrome c oxidase and ATPase genes. Functional studies of m...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 1 040 tis. Kč
    • •
  • 389 tis. Kč
    • •
  • MŠMT
Projekt

Genetice and metabolic consequences ofinherited disorders of mitochondrial ATFase. (NE6533)

Genetic and funtional characterization of mitochondrial encephalomyopathies caused by specific functional defects of mitochondrial ATP synthase due to mutations in mtDNA gene of subunit a, or by nuclear defects affecting biosynthesis of the ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 4 947 tis. Kč
    • •
  • 3 091 tis. Kč
    • •
  • MZ
Projekt

Phylogeography, selection and mutation rate at the whole-genome level Inference from mtDNA sequences of the house mouse (GA16-23773S)

this project aims to decipher several riddles of mtDNA evolution. Phylogeography and colonisation history of mtDNA haplotypes, their introgression across the HMHZ, rate-coding mtDNA regions or is it lineage-specific? The p...

EG - Zoologie

  • 2016 - 2020
    • •
  • 9 979 tis. Kč
    • •
  • 9 685 tis. Kč
    • •
  • GA ČR
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