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4 865 (0,141s) •

Projekt

The mechanism of the action of allosteric modulators of the metabotropic glutamate receptors (KJB5039402)

is the mechanism of the action of allosteric modulators within heptahelical domain and what with binding sites of the allosteric modulators. modulate neuronal signalization. Pharmacological diversity of m...

EA - Morfologické obory a cytologie

  • 2004 - 2006
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  • 2 479 tis. Kč
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  • 1 061 tis. Kč
    • •
  • AV ČR
Projekt

Dietary monoterpenoids as a novel class of aryl hydrocarbon receptor negative allosteric modulators in the therapy of colon cancer (GA23-04662S)

by preliminary data, where we reported monoterpenoid S-carvone as negative allosteric modulator of the AhR in vitro and in vivo. The AhR-antagonist capability of lead undescribed. We aim to develop first-in-class atypical ...

Biochemistry and molecular biology

  • 2023 - 2025
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  • 7 926 tis. Kč
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  • 7 926 tis. Kč
    • •
  • GA ČR
Projekt

Allosteric modulation of muscarinic receptors (GA309/96/1287)

of their allosteric control. The proponents have discovered positive allosteric phenomena their classical ligands under the influence of certain allosteric effectors) and have and functional properties of the ...

ED - Fyziologie

  • 1996 - 1998
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  • 3 071 tis. Kč
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  • 2 040 tis. Kč
    • •
  • GA ČR
Projekt

Influence of allosteric modulators on specificity of coupling with G-proteins and desensitization of muscarinic receptors (GA305/05/0452)

. It is possible that changes in receptor conformation induced by allosteric modulators might, and in native tissues. Considering potential use of allosteric receptor modulators in human of heterotrimeric G protein...

ED - Fyziologie

  • 2005 - 2007
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  • 4 992 tis. Kč
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  • 4 992 tis. Kč
    • •
  • GA ČR
Projekt

Allosteric modulation of nicotinic receptors (IAA100110501)

We will study the influence of allosteric modulators on nicotinic acetylcholine receptor function. We will concentrate on analysis of physostigmine allosteric action on embryonic and adult mouse muscle nicotinic receptors. ...

BO - Biofyzika

  • 2005 - 2008
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  • 1 792 tis. Kč
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  • 1 792 tis. Kč
    • •
  • AV ČR
Projekt

Allosteric regulation of muscarinic acetylcholine receptors (GA309/99/0214)

the allosteric modulators affect the ´active state´ of muscarinic receptors induced and functions of the allosteric binding sites on muscarinic receptors. Investigations of the allosteric regulation of muscarinic ...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
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  • 4 833 tis. Kč
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  • 4 146 tis. Kč
    • •
  • GA ČR
Projekt

Computer analysis of brain electric activity for evaluation of central nervous system functions (GA309/96/0959)

of their allosteric control. The proponents have discovered positive allostecic phenomena their classical ligands under the influence of certain allosteric effectors) and have and functional properties of the allosteri...

ED - Fyziologie

  • 1996 - 1998
    • •
  • 601 tis. Kč
    • •
  • 554 tis. Kč
    • •
  • GA ČR
Projekt

Molecular mechanisms of allosteric modulation of muscarinic acetylcholine receptors by neurosteroids and cholesterol (GA19-05318S)

sterol-based allosteric modulators and cholesterol at the molecular level...

Physiology (including cytology)

  • 2019 - 2021
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  • 7 213 tis. Kč
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  • 7 015 tis. Kč
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  • GA ČR
Projekt

Novel pharmacological strategies to target the sensor domain of temperature-activated TRPV channels (GA24-10147S)

strategies of their allosteric modulation. We aim to explore a novel class of modulators site in TRPV2 that is under allosteric control of the sulfonamide derivative......

Biophysics

  • 2024 - 2026
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  • 7 889 tis. Kč
    • •
  • 7 750 tis. Kč
    • •
  • GA ČR
Projekt

Allosteric communication in membrane protein complexes linked to conformational transitions on multiple timescales (GJ20-11563Y)

Allosterically modulated molecular machines mediate many of the key processes in all forms of life. The Sec translocon, a membrane bound protein complex SecYEG channel allosterically dependent on nucleotide state. We presen...

Biophysics

  • 2020 - 2022
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  • 4 713 tis. Kč
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  • 4 713 tis. Kč
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  • GA ČR
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