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Projekt

The role of CMTM4 in IL-17 receptor signaling (GJ20-24912Y)

The cytokine IL-17 functions as a crucial mediator of inflammation. Patients unable to signal via IL-17 suffer from chronic candidiasis, while aberrant production of IL-17 promotes a variety of au...

Cell biology

  • 2020 - 2022
    • •
  • 8 436 tis. Kč
    • •
  • 8 436 tis. Kč
    • •
  • GA ČR
Projekt

Elucidation of molecular mechanisms guiding assembly and function of IL-17-receptor signaling complex. (GJ17-27355Y)

The cytokine IL-17 is a crucial mediator of inflammation. Binding of IL-17 against invading pathogens. However, the dysregulation of IL-17 production or signaling through the IL-17

EC - Imunologie

  • 2017 - 2021
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  • 7 290 tis. Kč
    • •
  • 7 290 tis. Kč
    • •
  • GA ČR
Projekt

The effect of anti IL-17 therapy on skin and gut microbiota and intestinal barrier function in psoriasis patients (NU22J-05-00056)

IL-17 inhibitors have recently emerged as effective and safe therapy for the treatment of severe psoriasis with a very rapid onset of action. Although IL-17 occasionally associated with the development of inflammat...

Immunology

  • 2022 - 2025
    • •
  • 6 524 tis. Kč
    • •
  • 6 524 tis. Kč
    • •
  • MZ
Projekt

Small protein blockers of IL-23/IL-17 axis as intestinal inflammation inhibitors secreted by probiotic bacteria. (GF21-16423K)

of experimental colitis. To this goal we will use L. lactis secreting blockers of IL-23 cytokine (ILP binders), blockers of IL-23 receptor (REX ligands), and plan to generate novel set of L. lactis strains secreting already develop...

Health-related biotechnology

  • 2021 - 2024
    • •
  • 11 238 tis. Kč
    • •
  • 11 238 tis. Kč
    • •
  • GA ČR
Projekt

Monocyte subpopulations in kidney transplantation and regulatory mechanisms of human macrophage differentiation (NS10524)

production. Cytokines from IL-1 family (IL-1beta, IL-18, IL-33) and TNF alfa and furthermore, cytokines associated withTh1/Th2/Th17 polarization (IFN gama, IL-4, IL-13, IL-23, IL

EC - Imunologie

  • 2009 - 2011
    • •
  • 4 206 tis. Kč
    • •
  • 4 206 tis. Kč
    • •
  • MZ
Projekt

Angiogenesis, plasma cell kinetics, parameters of microenvironments of bone marrow and bone metabolism in monoclonal gammopathy of undetermined significance and initial phases of multiple myeloma (NR9500)

Comparison of microvessel density and endothelial-cell proliferation inside bone marrow and serum levels of angiogenic cytokines (VEGF, HGF, bFGF, IL-17, endoglin, angiogenin and angiostatin) in MGUS, smoldering (SMM) and overt form...

FD - Onkologie a hematologie

  • 2007 - 2009
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  • 4 306 tis. Kč
    • •
  • 4 191 tis. Kč
    • •
  • MZ
Projekt

Analysis of intracellular IL-1RA isoforms in patients with juvenile idiopathic arthritis and their relation to clinical features of the disease (NR7922)

Differentiation of production of IL-1RA izoforms in cell populations in peripheral blood/synovial tissue of JIA patients and peripheral blood of controls and IL-1RN*1/1, IL-1RN*1/2 a IL-1RN*2/2 genotypes in JIA pat...

FG - Pediatrie

  • 2004 - 2006
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  • 5 022 tis. Kč
    • •
  • 4 826 tis. Kč
    • •
  • MZ
Projekt

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone ...

Oncology

  • 2022 - 2024
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  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Projekt

Predictive immunological markers in patients with hepatitis C viral infection (NT14072)

in laboratory in Prague using FlowCytomix methodology: IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IFNg, TGF-b and TNF? and 4) Next imunological markers will be assessed......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
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  • 7 567 tis. Kč
    • •
  • 7 567 tis. Kč
    • •
  • MZ
Projekt

IL-35 a novel cytokine in systemic rheumatic diseases (NT12440)

IL-35 is a novel cytokine of IL-12 family with unknown functions in human diseases. Since our discovery of increased IL-35 in synovial fluid, its association) is a newfinding; our aims are to analyze serum levels of IL<...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2011 - 2014
    • •
  • 7 701 tis. Kč
    • •
  • 7 701 tis. Kč
    • •
  • MZ
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