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1 877 (0,088s) •

Projekt

Baroreflex sensitivity in adolescents with hypertension. (IZ3900)

Low baroreflex sensitivity(BRS) play a role in the development of hypertension in adults.The aim of the study is to assess the prognostic value of BRS for the development of essential hypertension in adolescents.......

FG - Pediatrie

  • 1997 - 1999
    • •
  • 658 tis. Kč
    • •
  • 604 tis. Kč
    • •
  • MZ
Projekt

Contribution of the RAAS to the pathophysiology of salt-sensitive hypertension a study in renin transgenic rats with inducible hypertension (GP305/08/P053)

-aldosterone system (RAAS) in the development of salt-sensitive hypertension. This study should address the issue whether the salt sensitivity is the result of increased ofrenin transgenic rats with inducible hypertensi...

ED - Fyziologie

  • 2008 - 2010
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  • 1 485 tis. Kč
    • •
  • 1 485 tis. Kč
    • •
  • GA ČR
Projekt

Neurohumoral control of calcium influx nifedipine-sensitive component of blood pressure in experimental hypertension (IAA500110902)

Both spontaneous and salt hypertension are characterized by sympathetic systems. The dominance of vasoconstrictor over vasodilator mechanisms in hypertensive rats is associated with enhanced nifedipine-sensitive blood press...

ED - Fyziologie

  • 2009 - 2011
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  • 4 157 tis. Kč
    • •
  • 4 157 tis. Kč
    • •
  • AV ČR
Projekt

on pathophysiology of salt-sensitive hypertension and renal injury (LH11116)

and its impact on pathophysiology of salt-sensitive and angiotensin II-dependent hypertension and end-organ damage. Furthermore, pharmacological intervention to RAAS and thus may contribute to the pathophysiology of salt-sensit...

ED - Fyziologie

  • 2011 - 2013
    • •
  • 1 120 tis. Kč
    • •
  • 1 120 tis. Kč
    • •
  • MŠMT
Projekt

Systems genetic approach for identifying genes predisposing to salt-sensitive hypertension in the rat (LUAUS25164)

pressure, while others are salt resistant. The spontaneously hypertensive rat (SHR) is a key model for the study of salt-sensitive hypertension. In search of the molecular mechanisms underlying salt-sensitive ...

Cardiac and Cardiovascular systems

  • 2025 - 2028
    • •
  • 5 172 tis. Kč
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  • 5 172 tis. Kč
    • •
  • MŠMT
Projekt

THE RELATIONSHIP BETWEEN BAROREFLEX SENSITIVITY AND PARAMETERS OF THE CAROTID WALL MEASURED SONOGRAPHCALLY (NA7362)

Decreased baroreflex sensitivity takes part in the development of hypertension the arterial wall, and thus the sensitivity of receptors. The thickness of the carotid artery wall will be correlated with baroreflex sensit...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 1 917 tis. Kč
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  • 1 724 tis. Kč
    • •
  • MZ
Projekt

European Project on Genes in Hypertension (EPOGH) (OK 375)

EPOGH is a multicentric comparative European study focused on blood pressure; families from general population and families of hypertensive patients will be studied. Complex phenotypes and genetic analysis will be assessed. Studies of phenot...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1999 - 2002
    • •
  • 1 197 tis. Kč
    • •
  • 1 157 tis. Kč
    • •
  • MŠMT
Projekt

Central and peripheral modulation of vascular tone and sodium excretion the role of brain and kidney in pathophysiology of hypertension (NV15-25396A)

of several forms of experimental hypertension resembling human salt-sensitive or saltBrain and kidney play essential role in the pathogenesis of hypertension of vascular tone and is also responsible for abnormal renal func...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2019
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  • 9 534 tis. Kč
    • •
  • 9 534 tis. Kč
    • •
  • MZ
Projekt

Positional cloning of a gene on chromosome 18 that is repsonsible for hypertension and salt sensitivity in the spontaneously hypertensive rat (GA301/04/0390)

congenicstrain, to genetically isolate QTL responsible for hypertension and salt sensitivityPrevious linkage studies in the spontaneously hypertensive rat (SHR) suggested the presence of a major quantitative trait locus (Q...

EB - Genetika a molekulární biologie

  • 2004 - 2006
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  • 3 828 tis. Kč
    • •
  • 3 828 tis. Kč
    • •
  • GA ČR
Projekt

Pathophysiological mechanisms of spontaneous hypertension and salt sensitivity (NR8545)

The isolated infuence of genes localized in segment of chromozoma 18 on hypertension will be investigated using renal transplantation of kidneys from SHR-18 congenic strain into SHR recipients. The gene expression profiling of kidneys obtain...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
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  • 3 025 tis. Kč
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  • 2 985 tis. Kč
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  • MZ
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