Filtry
Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)
B-chronic lymphocytic leukemia (B-CLL) is most frequent leukemia in adult age incurable with conventional therapy. B-CLL tumour cells are weakly immunogenic which may that enhance the imm...
EC - Imunologie
- 2008 - 2010 •
- 1 230 tis. Kč •
- 1 230 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia (NT11217)
The proposed project attempts to clarify the role of non-canonical Wnt pathway in diagnosis, prognosis and in molecular pathogenesis of chronic lymphocytic leukemia (CLL). The proposed goal will be achieved by expression an...
FD - Onkologie a hematologie
- 2010 - 2014 •
- 9 860 tis. Kč •
- 9 860 tis. Kč •
- MZ
Řešení projektu: 1. 9. 2010 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
ROR1-positive peripheral blood b-cells of healthy donors and their connection to chronic lymphocytic leukemia development (GA23-05561S)
to aging and chronic lymphocytic leukemia (CLL) development. So far, only immature ROR1+ B cells were described, however our data show that these populations contain also mature B cells, including memory ...
Cell biology
- 2023 - 2025 •
- 10 232 tis. Kč •
- 10 232 tis. Kč •
- GA ČR
Řešení projektu: 1. 3. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
NON-CODING RNAS IN MICROENVIRONMENTAL INTERACTIONS OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA (GX25-15368X)
’ role in B cell receptor (BCR) signaling and B-T cell interactions. These microenvironmental pathways are essential for normal B cell functions and are frequently dysregulated in “mature” B cell neoplasms. Chr...
Cell biology
- 2025 - 2029 •
- 49 937 tis. Kč •
- 49 937 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2029
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)
Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity concerning clinical presentation and molecular features. As the clonal disease of B lymphocytes, each case can be describe...
FD - Onkologie a hematologie
- 2015 - 2018 •
- 15 351 tis. Kč •
- 15 028 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2015 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Ministerstvo zdravotnictví
Identification of novel molecular pathways involved in the process of B-cell allelic exclusion; chronic lymphocytic leukemia as the model system (NS9652)
of B-lymphocytes. The process is strictly controlled and aberrant B-lymphocytes, expressing two IgVH alleles, are eliminated. Chronic lymphocytic leukemia (CLL) is a clonal disorder of <...
FD - Onkologie a hematologie
- 2008 - 2011 •
- 8 112 tis. Kč •
- 8 082 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Molecular Characterization of B-cell Receptors and Their Relationship to Evolution of Gemonic Aberrations in Chronic Lymphocytic Leukemia (NT13493)
Variable course of chronic lymphocytic leukemia (CLL) is influenced by many factors. The signalization via B-cell receptor (BCR) belongs among them; its intensity depends on the molecular properties of BCR. This re...
FD - Onkologie a hematologie
- 2012 - 2015 •
- 8 737 tis. Kč •
- 8 737 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
High throughput detection of genetic alterations in chronic lymphocytic leukemia using array comparative genomic hybridization (NR9484)
I. The utilization of array comparative genomic hybridization (array-CGH) for determination of DNA copy number changes in patients with chronic B lymphocytic leukemia (B-CLL). II. The utilization of specif...
FD - Onkologie a hematologie
- 2007 - 2009 •
- 8 360 tis. Kč •
- 7 861 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (94%)
Poskytovatel: Ministerstvo zdravotnictví
The role of sphingosine-1-phosphate receptor 1 in B cell mechanosensitivity. (GA25-16907S)
Migrating lymphocytes encounter number of signals guiding them through tissues cues affect lymphocyte migration is unknown. We discovered that mechanical confinement triggers rapid motility of primary B cells in the absence...
Cell biology
- 2025 - 2027 •
- 11 919 tis. Kč •
- 11 919 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Selection of genomic defects in chronic lymphocytic leukemia and their impact on disease outcome (NV15-31834A)
In chronic lymphocytic leukemia (CLL), the absence of primary genomic defect implies that various circumstances, represented by both intrinsic and extrinsic factors, have to be met to support leukemic clone selection, growt...
FD - Onkologie a hematologie
- 2015 - 2018 •
- 9 912 tis. Kč •
- 9 912 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2015 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
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