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2 899 (0,1s) •

Projekt

HMGB1 role in modulation of tumor suppressors and telomere integrity (GA204/05/2031)

and metastasis) could differentially modulate p53-dependent transactivation of genes involved is to decipher arole of Rb and HMGBl in p53/p73-dependent transactivation of p53-responsive genes and to identify prote...

CE - Biochemie

  • 2005 - 2007
    • •
  • 3 528 tis. Kč
    • •
  • 3 528 tis. Kč
    • •
  • GA ČR
Projekt

DNA binding, stress-induced expression and transactivation activity of p73 protein isoforms (GAP301/11/2076)

Protein p73, a member of p53 family of transcription factors, shares remarkable homology with p53 protein and is able to transactivate many of p53-downstream genes influence gene expression. This project is focused (ii) on ...

EB - Genetika a molekulární biologie

  • 2011 - 2015
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  • 5 953 tis. Kč
    • •
  • 5 953 tis. Kč
    • •
  • GA ČR
Projekt

Non-canonical signaling of human receptor tyrosine kinases (GA17-09525S)

that unrelated RTKs may interact and activate (transactivate) each other. These non-canonical-out to date, to unravel existing transactivations among all known human RTKs. Subsequently, we will define the molecular mechanisms of RT...

CE - Biochemie

  • 2017 - 2021
    • •
  • 9 126 tis. Kč
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  • 9 126 tis. Kč
    • •
  • GA ČR
Projekt

Identification of interactors of the meiotic histone methyltransferase Hybrid sterility 1 (PR-domain 9) (GAP305/10/1931)

for a speciationgene. The product of this gene, PRDM9, transactivates other genesThe proposal of this project is based on our recent discovery of a gene participating in a multigenic type of hybrid sterility. The ...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 6 107 tis. Kč
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  • 6 107 tis. Kč
    • •
  • GA ČR
Projekt

Functional analysis of temperature sensitive mutants of tumor suppressor p53 (NR8068)

In the submitted project we propose to analyze temperature and cold senzitive mutations of tumor suppressor p53. We intend to quantify the level of their temperature sensitivity, site-specific transactivation ability and level of reactivatio...

EB - Genetika a molekulární biologie

  • 2004 - 2006
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  • 2 015 tis. Kč
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  • 1 946 tis. Kč
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  • MZ
Projekt

Determination of functional status of tumor suppressor p53 in acute myeloid leukemia by using of method FASAY. (NC6395)

The project concentrates on determination of functional status of tumor suppressor p53 in cells of patients with acute myeloid leukemia by functional method called FASAY,which is based on measuring of transactivation ability of p53 protein.....

FD - Onkologie a hematologie

  • 2000 - 2002
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  • 3 383 tis. Kč
    • •
  • 3 383 tis. Kč
    • •
  • MZ
Projekt

The Effect of Size and Sequence of Upstream ORF on the Ability of Transactivator Protein from Cauliflower Mosaic Virus to Activate the Expression of Tandem ORFs (GA204/93/0885)

9B - 9

  • 1993 - 1995
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  • 198 tis. Kč
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  • 396 tis. Kč
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  • GA ČR
Projekt

Mechanisms and Effects of Inverse TAp63 and ΔNp63 Regulation (GA23-05951S)

The TP63 gene produces two proteins from two separate promoters, TAp63 and ΔNp63. TAp63 contains a p53-like transactivation domain that is lacking from ΔNp63, making TAp63 a tumor suppressor and ΔNp63 an oncogene. The two proteins s...

Biochemistry and molecular biology

  • 2023 - 2025
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  • 9 589 tis. Kč
    • •
  • 9 418 tis. Kč
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  • GA ČR
Projekt

Comparative study of DNA interacting properties of the tumor suppressor p53 protein isoforms (GA18-15548S)

TP53 is the most frequently mutated gene in human cancers. Besides mutations it was demonstrated that the human TP53 gene encodes at least 12 p53 isoforms with different expression profiles in normal and cancer cells. It has been de...

Oncology

  • 2018 - 2020
    • •
  • 6 593 tis. Kč
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  • 6 398 tis. Kč
    • •
  • GA ČR
Projekt

Myb, Fos, Jun and retinoid receptor protein interactions in anti-leukemic processes (GA312/98/0679)

protein interactions for their DNA-binding - and transactivation abilities, on the genes which are controled by retinoid receptors and mediate the function of retinoid......

EB - Genetika a molekulární biologie

  • 1998 - 2000
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  • 1 654 tis. Kč
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  • 1 572 tis. Kč
    • •
  • GA ČR
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