Filtry
DNA quadruplexes in the human genome associated with diseases and aging (GAP205/12/0466)
will focus on quadruplexes formed by telomeric DNA and DNA of selected oncogenes. These quadruplexes influence aging and cancer, and thus have become targets for the designThere are numerous regions in the human g...
BO - Biofyzika
- 2012 - 2016 •
- 5 753 tis. Kč •
- 5 753 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Plant transposable elements and DNA conformation (GA15-02891S)
to form multi-stranded DNA, like quadruplexes and triplexes. We propose studying the distribution of quadruplexes in the main TE families (LTR- and nonLTR retrotransposons) in completely sequenced plant genomes. The abilit...
EB - Genetika a molekulární biologie
- 2015 - 2017 •
- 6 130 tis. Kč •
- 6 130 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2015 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Guanine quadruplex-mediated functions of p53, p63 and p73 proteins in cancer biology (GA19-15168S)
G-quadruplexes, non-B DNA structures, are linked to regulation of transcription, replication and genome stability. In the previous project, we showed that G-quadruplexes. Influence of DNA/RNA G-quadruplexes
Biochemistry and molecular biology
- 2019 - 2022 •
- 3 782 tis. Kč •
- 3 776 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 30. 6. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interactions of p53 family proteins with biologically significant DNA quadruplexes (GA13-36108S)
on DNA binding activities. Remarkable functional flexibility of p53 (from of p53 interaction with DNA. Human genome is enriched in DNA sequences with G-quadruplex-forming potential (repetitive sequences, oncogene ...
EB - Genetika a molekulární biologie
- 2013 - 2015 •
- 4 919 tis. Kč •
- 4 919 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The fascinating physical chemistry of DNA studied by advanced computations (GA21-23718S)
quadruplexes, short guanine-rich hairpins and i-DNA, sequence-dependent ability of Holliday junctions to form crystal lattices, binding and reaction mechanism of hemin-quadruplex-canonical DNA molecules, in a clos...
Physical chemistry
- 2021 - 2024 •
- 5 874 tis. Kč •
- 5 874 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 30. 6. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of transposable elements in the dynamics of plant genomes (GA18-00258S)
on recombination and genome size. In TEs, we will search for motifs (e.g. satellite DNA, microRNA, extraORFs, quadruplex DNA) that could regulate TE expansion and test our of quadruplex DNA on TE expressi...
Genetics and heredity (medical genetics to be 3)
- 2018 - 2022 •
- 8 731 tis. Kč •
- 7 844 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (90%)
Poskytovatel: Grantová agentura České republiky
Regulation of the embryonic stem cell pluripotency factor Oct4 via guanine quadruplex in its promoter (GP14-33947P)
DNA-binding domains of the SAF-A protein to elucidate the role of the quadruplex in this interaction; does the quadruplex serve as a conformational switch, dependent on binding are unusually guanine rich and, thus, may pot...
BO - Biofyzika
- 2014 - 2016 •
- 1 505 tis. Kč •
- 1 505 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Identification and characterization of proteins involved in G-quadruplex and R-loop metabolism and their relationship with DNA replication (GX21-22593X)
DNA replication is an essential and one of the most complex processes in the cell. Not only exogenous DNA damage but also intrinsic DNA structures including G-quadruplexes (G4) and R-loops, their stabilization or u...
Biochemistry and molecular biology
- 2021 - 2025 •
- 49 901 tis. Kč •
- 49 901 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Role of cytosine in the conformational polymorphism of DNA (IAA4004701)
) forms at neutral pH, and its role in the formation of cytosine i-quadruplex. The anomalousconformation of d(CnGn) oligonucleotides.Duplex,G-quadruplex and i-quadruplex formation in the d(CnGn) and d(GnCn) fragments of
BO - Biofyzika
- 1997 - 1999 •
- 3 750 tis. Kč •
- 1 425 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (38%)
Poskytovatel: Akademie věd České republiky
Biophysical characterization of guanine quadruplexes in the RNA genome of tick-borne encephalitis virus and elucidating their role in viral life cycle (GA20-20229S)
Guanine quadruplexes (G4) represent structurally diverse group of unusual of their cellular roles was reported. RNA quadruplexes are very stable, even in comparison to DNA, which supports their formation in vivo and their i...
Biophysics
- 2020 - 2023 •
- 10 753 tis. Kč •
- 10 753 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 30. 6. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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