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56 (0,072s) •

Projekt

The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension (NS9699)

This proposal is designed to determine whether inhibitors of soluble epoxide hydrolase (sEH), increasing endogenous level of epoxyeicosatrienoic acids (EETs), could be a potential new approach in antihypertensive drug therapy. An ef...

ED - Fyziologie

  • 2008 - 2011
    • •
  • 3 119 tis. Kč
    • •
  • 3 119 tis. Kč
    • •
  • MZ
Projekt

Investigations into regioselectivity of evolved epoxide hydrolases (GAP207/10/0135)

The project aims for a deeper understanding of an important but yet neglected characteristic of epoxide hydrolases (EHs): regioselectivity. Structure-function relationships will be approached using directed evolution of the substrat...

EI - Biotechnologie a bionika

  • 2010 - 2012
    • •
  • 2 507 tis. Kč
    • •
  • 2 507 tis. Kč
    • •
  • GA ČR
Projekt

Analysis of microbial communities from different aquatic habitats specific transcriptomics in relation to pollution by volatile organic compounds (GAP504/10/0137)

haloalkane dehalogenases (HADs) and epoxide hydrolases (EHs), which are key enzymes in the biodegradation of halogenated VOCs and epoxides. The entire microbial community of microbial genes involved in biodegradation of ha...

EH - Ekologie – společenstva

  • 2010 - 2012
    • •
  • 2 289 tis. Kč
    • •
  • 2 289 tis. Kč
    • •
  • GA ČR
Projekt

Construction and exploration of more effective gene libraries comprising the total microbial environmental gene pool (DNA and mRNA) of polluted sites (GA204/06/0458)

encoded by new pyranose oxidase and epoxide hydrolase genes. We will use substrates libraries, using pyranose oxidases and epoxide hydrolases as......

EI - Biotechnologie a bionika

  • 2006 - 2008
    • •
  • 1 614 tis. Kč
    • •
  • 1 614 tis. Kč
    • •
  • GA ČR
Projekt

Renal Autoregulation and Pressure Natriuresis in Experimental Model of Renovascular Hypertension (GPP303/10/P170)

Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are d...

ED - Fyziologie

  • 2010 - 2013
    • •
  • 1 685 tis. Kč
    • •
  • 1 685 tis. Kč
    • •
  • GA ČR
Projekt

The role of interaction of the cytochrome P450-derived eicosanoids and the renin-angiotensin system in the pathophysiology of congestive heart failure combined with chronic kidney disease. (NT14012)

Recent studies have proposed that in the pathophysiology of progression of congestive heart failure combined with chronic kidney disease rather the interaction of renin-angiotensin-aldosterone system (RAAS) with other vasoactive systems has more impo...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 5 211 tis. Kč
    • •
  • 5 211 tis. Kč
    • •
  • MZ
Projekt

Catalytic oxidation of alkenes (TA03011148)

Project Catalytic oxidation of alkenes consists of an applied research / experimental development of new catalytic systems of processes for epoxides production by direct catalytic epoxidation of alkenes, in particular allylchloride,...

CI - Průmyslová chemie a chemické inženýrství

  • 2013 - 2016
    • •
  • 27 988 tis. Kč
    • •
  • 13 973 tis. Kč
    • •
  • TA ČR
Projekt

The biolubricants preparation from renewable sources (EG20_321/0024864)

The aim of the project is to develop an epoxidation process enabling, viscosity number compared to the starting materials. In the epoxidation process the epoxidation process. This creates a large amount of wastewater. The d...

Organic chemistry

  • 2021 - 2024
    • •
  • 7 118 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Projekt

Development of high solid coating system (TC5-051)

The aim of project is introducing home produce of decontamination coating system on basis of high solid epoxide and polyuretanic paints....

CI - Průmyslová chemie a chemické inženýrství

  • 1999 - 2001
    • •
  • 6 000 tis. Kč
    • •
  • 3 000 tis. Kč
    • •
  • MH
Projekt

Cardioprotective and antihypertensive effects of agonistic epoxyeicosatrienoic acids analogs. (GA15-07544S)

is limited by their relatively rapid degradation by soluble epoxide hydrolase enzyme (sEH...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2017
    • •
  • 6 032 tis. Kč
    • •
  • 6 032 tis. Kč
    • •
  • GA ČR
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