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5 860 (0,106s) •

Projekt

Molecular and cellular consequences of p53 manipulation using heat shock protein inhibitors and E3-ligases. (GA301/08/1468)

The level of p53 in normal cells is tightly regulated via induced degradation through the ubiquitin/proteasome system. MDM2 is major regulator of wild-type p53 to wild-type p53 and this i...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 3 063 tis. Kč
    • •
  • 2 925 tis. Kč
    • •
  • GA ČR
Projekt

Interactions of tumor suppressor proteins with DNA. Roles of DNA conformation and protein modifications (GA204/02/0734)

wild type p53 binds with a strong preference: Palecek et al., Oncogene 1997, 15 of the protein to these structures will be studied using wild type p53 as well as deletionThe ability of tumor supp...

CE - Biochemie

  • 2002 - 2004
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  • 4 448 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
Projekt

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its biological activities. It was suggested that not only the wild type (wt) p53 sequence-specific DNA binding, but also ability of both wt and ...

EB - Genetika a molekulární biologie

  • 2007 - 2010
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  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Projekt

Mechanism of non-mutational p53 inactivation in human cancers and its implication for cancer therapy (GJ19-18177Y)

50 % of cancers retain wild-type p53 but its function is often restricted. Despite the tremendous knowledge about p53, the mechanisms underlying non-mutational inactivation are unknown. To identify essential factor...

Oncology

  • 2019 - 2022
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  • 7 281 tis. Kč
    • •
  • 7 281 tis. Kč
    • •
  • GA ČR
Projekt

Characterizing the role of p53-mediated enhancement of TRAIL-R2 and CD95 expression in the induction of apoptosis by TRAIL and CD178 (NC7133)

that have either wild-type or suppressed p53 activity.This project aims to provide direct and unambiguous evidence that the upregulation of expression of death receptors TRAIL-R2 and CD95 mediated by p53 transcrip...

FD - Onkologie a hematologie

  • 2002 - 2003
    • •
  • 1 357 tis. Kč
    • •
  • 1 261 tis. Kč
    • •
  • MZ
Projekt

Interaction proteins with surfaces. New biophysical methods for analysis of tumor supressos protein p53 (GP202/07/P497)

of the investigated protein. Wild type and mutant p53 proteins will be studied by electrochemical suppressor function of the p53 protein and enhance the metastatic potential. Point these methods for biophysical in...

BO - Biofyzika

  • 2007 - 2009
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  • 1 164 tis. Kč
    • •
  • 1 164 tis. Kč
    • •
  • GA ČR
Projekt

Functional analysis of the p53-dependent pathways in breast cancer Integration of genomic and proteomic approaches using DNA-macroarray and SELDI-TOF mass spectrometry techniques (NR8338)

of posttranslationally modified wild-type p53 and mutant p53 proteins and cancer progression and itsThe analysis of the p53 pathway and its functional status in breast carcinomas molecular signalling path...

FD - Onkologie a hematologie

  • 2005 - 2007
    • •
  • 13 003 tis. Kč
    • •
  • 12 992 tis. Kč
    • •
  • MZ
Projekt

Interactions of supercoiled DNA with tumor-supressor protein p53 (IAA5004803)

the information and experience obtained during the studies of the wild type p53 protein willbeThis project is oriented towards the biophysical studies of p53 and its on the p53 protein binding to DNA incl...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 899 tis. Kč
    • •
  • 990 tis. Kč
    • •
  • AV ČR
Projekt

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

The tumor suppressor protein p53 plays a critical role in the control of cell suppressor function of the p53 protein and gain-of-function enhancing the tumorogenicity of mutated p53, including DNA binding. Almost nothing is...

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Projekt

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

, quadruplexes). The p53 protein is the most frequently mutated transcription factor in human cancers. Wild-type p53 binds DNA sequence-specifically, but also recognizes various non-B DNA structures. Most missense ...

Oncology

  • 2022 - 2024
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  • 7 056 tis. Kč
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  • 7 056 tis. Kč
    • •
  • GA ČR
  • 1 - 10 z 5 860