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5 532 (0,162s) •

Projekt

The preparation of enantiopure helically chiral aromatics and their use in catalysis (GA14-29667S)

The project is focused on the development of a practical approach to enantiopure functionalised helical (hetero)aromatics employing enantioselective [2+2+2] cycloisomerisation of alkynes/nitriles. (Hetero)dibenzohe...

CC - Organická chemie

  • 2014 - 2016
    • •
  • 8 851 tis. Kč
    • •
  • 8 851 tis. Kč
    • •
  • GA ČR
Projekt

Giant nonplanar aromatics The quest for new functional materials (GA16-08294S)

The project aims at developing synthetic methodologies for the preparation of axially and laterally extended helicenes, their multiple/fused analogues, circulenes and cycloarenes. These unique nonplanar polyaromatics and optionally their properly fun...

CC - Organická chemie

  • 2016 - 2018
    • •
  • 7 968 tis. Kč
    • •
  • 6 894 tis. Kč
    • •
  • GA ČR
Projekt

Exploring Helically Chiral Ligands in Enantioselective Transition Metal Catalysis (GA203/09/1766)

) and enantioselective cyclisations (C-C bond forming reactions such as metallo-ene reaction, [2+2+2] cycloisomerisation, gold-catalysed cyclisations). Ab initio methods will be usedto optimise......

CC - Organická chemie

  • 2009 - 2013
    • •
  • 5 034 tis. Kč
    • •
  • 5 034 tis. Kč
    • •
  • GA ČR
Projekt

Enantioselective catalysis under the control of helical chirality (GA19-10144S)

catalysed by transition metals such as alkyne cycloisomerisation, olefin metathesis...

Organic chemistry

  • 2019 - 2023
    • •
  • 7 872 tis. Kč
    • •
  • 6 369 tis. Kč
    • •
  • GA ČR
Projekt

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone ...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Projekt

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e to understanding the mechanism how these complexes interact with high affinity trimeric IL-2 receptor. JES6-1 mAb sterically blocks the interaction...

Immunology

  • 2018 - 2022
    • •
  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Projekt

Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)

It has been shown previously that complexing IL-2 with certain anti-IL-2 mAb enourmously increases activity of IL-2 in vivo. These immunocomplexes selectively stimulate different subsets of immune cells depending on clone ...

EC - Imunologie

  • 2013 - 2018
    • •
  • 11 872 tis. Kč
    • •
  • 11 872 tis. Kč
    • •
  • GA ČR
Projekt

*Modernization of the VS 2 ejection seat. (FT-TA3/046)

*Modernization of the VS 2 ejection seat....

JU - Aeronautika, aerodynamika, letadla

  • 2006 - 2008
    • •
  • 35 869 tis. Kč
    • •
  • 18 212 tis. Kč
    • •
  • MPO
Projekt

Study of anion processes relevant for astrophysics (7AMB14AT023)

The primary objective of the project on the czech side is the measurement of the temperature dependence of the rate coefficients of O - + H 2 -> H 2 O + e - O - + H 2 of the isotopicexchange H 2 /D 2 . The...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2015
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Projekt

Aspects of immune response and efficacy of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients (NU22-C-126)

1) Evaluate safety and imunogenicity of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients. 2) Evaluate association between booster dose of SARS-CoV-2 mRNA vaccine and risk of SARS-CoV-2 infect...

Transplantation

  • 2022 - 2023
    • •
  • 6 194 tis. Kč
    • •
  • 6 194 tis. Kč
    • •
  • MZ
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