Filtry
Primary ciliary dyskinesia new approaches to diagnostics and epidemiology (NT11469)
Submitted project is concerned with primary ciliary dyskinesia diagnostics. Primary ciliary dyskinesia is a genetic disorder and their diagnostic protocol is appreciably complicated. Indicative criteria determination and designation...
FG - Pediatrie
- 2010 - 2014 •
- 6 588 tis. Kč •
- 6 588 tis. Kč •
- MZ
Řešení projektu: 1. 9. 2010 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Primary ciliary dyskinesia Genetic, structural and functional determinants of the disease course and prognosis. (NV19-07-00210)
too late. Diagnosis is based on clinical suspicion, ciliary function testsPrimary ciliary dyskinesia (PCD) is a rare disease with recessive inheritance. Dysfunctional cilia lead to serious deficit of defence mechanisms of ...
Respiratory systems
- 2019 - 2022 •
- 9 560 tis. Kč •
- 9 560 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2019 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Functional and ultrastructural examination of respiratory cilia in adult patients suffering from chronic obstructive pulmonary disease. (NR8407)
The main aim of our study is to detect presence of secondary ciliary dyskinesia in patients with COPD and also more detailed phenotypic description. The second intention of our project is to compare ciliary structure and functions o...
FC - Pneumologie
- 2005 - 2008 •
- 3 799 tis. Kč •
- 3 782 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2005 - 31. 12. 2008
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Reconstructing urbilaterian photoreceptors comparative study between Branchiostoma (Chordata) and Platynereis (Annelida). (GCP305/10/J064)
Despite the enormous diversity of bilaterian eyes, their basic units ? photoreceptor cells ? can be classified into two types - ciliary and rhabdomeric. Some molecular components, such as opsins, are common for both types and seem to have be...
EB - Genetika a molekulární biologie
- 2010 - 2013 •
- 5 100 tis. Kč •
- 5 100 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2010 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
On the Trail of the Tubulin Code Exploring Ciliopathy Mechanisms and Therapeutic Opportunities (GA26-21078S)
Ciliopathies are a group of disorders characterized by dysfunctional cilia, small sensory membrane protrusions found on nearly all human cells. Bardet-Biedl Syndrome (BBS) is a rare multisystemic ciliopathy caused by malfunction of a ciliary...
Cell biology
- 2026 - 2028 •
- 11 522 tis. Kč •
- 11 522 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2026 - 31. 12. 2028
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Using cryo-electron tomography for understanding function of the ciliary tip domain (GC20-23165J)
Cilia and flagella are highly evolutionarily conserved organelles on the surface of many eukaryotic cells, ranging from protists to most human cell types. They have fundamental motility, signaling and sensory roles. The axoneme, a highly organized cy...
Cell biology
- 2020 - 2022 •
- 7 398 tis. Kč •
- 7 398 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Molecular mechanisms of protein sorting in sensory cilia (GM26-22371M)
of ciliary proteins, with disruptions leading to ciliopathies. The mechanisms by which IFT regulates protein entry and exit to maintain ciliary compartmentalization......
Cell biology
- 2026 - 2030 •
- 24 956 tis. Kč •
- 24 956 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2026 - 31. 12. 2030
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Primary ciliary aplasia (OK 266)
Isolation of gamma-tubulins from RBL cells and from brain tissue on preparative columns with bound TU-31 antibody. Electrophoretic analysis of isolated gamma-tubulins by 2D-electrophoresis and by high-resolution isoelectric focusing. Biochemical anal...
EI - Biotechnologie a bionika
- 1997 - 1999 •
- 3 780 tis. Kč •
- 2 080 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (55%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Genetic, transcriptomic and molecular characterization of photoreceptors in the basal chordate amphioxus (GA20-25377S)
ciliary and rhabdomeric sub-types. Recent breakthrough advances in molecular techniques, such as single-cell transcriptomics or CRISPR/Cas9-based functional studies......
Developmental biology
- 2020 - 2022 •
- 8 799 tis. Kč •
- 8 799 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
BBSome and actin interplay in ciliogenesis and formation of the immunological synapse (GJ17-20613Y)
The proposed project focuses on the interplay between protein transport complex BBSome and actin cytoskeleton during formation of two homologous structures, primary cilia and the immunological synapse. BBSome is essential for targeting specific membr...
EB - Genetika a molekulární biologie
- 2017 - 2021 •
- 8 061 tis. Kč •
- 8 061 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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