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11 (0,129s) •

Projekt

OXPHOS Addiction as a New Hallmark in Cancer Its Use for Development of Novel, Efficient Cancer Therapy (NV17-30138A)

In spite of concerted effort, a number of types of cancer are very hard to cure or are beyond any treatment with resection being the only option in a limited number of patients. Therefore, new and efficient therapeutic approach is needed. We have rec...

FD - Onkologie a hematologie

  • 2017 - 2020
    • •
  • 16 490 tis. Kč
    • •
  • 15 226 tis. Kč
    • •
  • MZ
Projekt

Determination of effects of aromatic contaminants on the hepatic detoxifying systems, their immunotoxicity and biochemical monitoring (RE0930950044)

DN - Vliv životního prostředí na zdraví

  • 1993 - 1995
    • •
  • 980 tis. Kč
    • •
  • 1 960 tis. Kč
    • •
  • MZe
Projekt

Signal transduction in lymphoid cells mediated by non-receptor protein tyrosine kinases of the Src and Syk families. (IZ3517)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 1 707 tis. Kč
    • •
  • 1 096 tis. Kč
    • •
  • MZ
Projekt

Protein markers of honeybee disseases (LD15028)

The aim of this project is to gain using proteomic methods new knowledge in the field of biology of honeybee, honeybee pathogens, pathogen phosphorylation sites in honeybees and Varroa mite, and influence of agrochemicals on honeybee health. The resu...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2015 - 2017
    • •
  • 1 688 tis. Kč
    • •
  • 1 688 tis. Kč
    • •
  • MŠMT
Projekt

New approaches to non-invasive diagnostics of mitochondrial diseases (NV19-07-00149)

Mitochondrial diseases are caused by insufficient function of energy provision apparatus and they belong among the most severe inborn errors of metabolism. Whole exome sequencing helped to characterise many causal mutations, but as of yet, almost 40%...

Paediatrics

  • 2019 - 2022
    • •
  • 14 521 tis. Kč
    • •
  • 14 521 tis. Kč
    • •
  • MZ
Projekt

Preclinical applications of beauverolides, cyclodepsipeptides of entomopathogenic fungi (NV15-32432A)

Beauverolides represent a group of fungal cyclotetradepsipeptides, with only recently recognized potential for human medicine. Reflecting recent preclinical data, this project focuses at the use of beauverolides in modulation of pathologies associate...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2019
    • •
  • 8 383 tis. Kč
    • •
  • 8 383 tis. Kč
    • •
  • MZ
Projekt

New target genes for childhood leukemia diagnosis and treatment focused on adaptor molecules of signaling pathways (2B06064)

The aim of this project is a generation of new diagnostic and terapeutic means for human cancer. New childhood leukemia-specific target genes will be selected based on meta-analysis of differentially expressed transcripts from available published exp...

FD - Onkologie a hematologie

  • 2006 - 2011
    • •
  • 29 140 tis. Kč
    • •
  • 25 820 tis. Kč
    • •
  • MŠMT
Projekt

The role of oxidative stress in the healing of pressure ulcers in patients with spinal cord lesions (NU21-09-00541)

Pressure ulcers as chronic wounds significantly reduce the quality of life of the patient, but also represent a significant financial burden on the health system. Although the surgical treatment of pressure ulcers is lengthy, it leads to the healing ...

Surgery

  • 2021 - 2024
    • •
  • 9 925 tis. Kč
    • •
  • 9 925 tis. Kč
    • •
  • MZ
Projekt

Novel anticancer platinum complexes - mechanisms of their action and innovative chemotherapy strategies (GA301/07/1557)

The role of (phospho-)lipid metabolism, and notably of polyunsaturated fatty acids, in effects a) of cisplatin and b) of novel highly efficient platinum cytostatics LA-9 and LA-12, originally synthesized in the Czech Republic, will be investigated in...

FD - Onkologie a hematologie

  • 2007 - 2011
    • •
  • 7 577 tis. Kč
    • •
  • 7 577 tis. Kč
    • •
  • GA ČR
Projekt

Receptor tyrosin kinases and downstream signaling pathways as possible therapeutic targets in pediatric refractory solid tumors (NV16-34083A)

This project is aimed at a detailed analysis of activity of the RTK and the downstream signaling pathways in high-risk refractory pediatric solid tumors. Individual or paired samples of tumor tissue taken from the individual patients should be includ...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 14 468 tis. Kč
    • •
  • 14 468 tis. Kč
    • •
  • MZ
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