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1 130 (0,094s) •

Projekt

Chicken polymorphisms in retroviral receptors and their potential for cross-species transmission (GA13-30983S)

in chicken XPR1, ASCT1, and Tvj, receptors for murine xenotropic viruses, endogenous pseudotypes carrying reporter and different retroviral glycoproteins, we will correlate the receptor variants with susceptibility or res...

EB - Genetika a molekulární biologie

  • 2013 - 2017
    • •
  • 5 930 tis. Kč
    • •
  • 5 930 tis. Kč
    • •
  • GA ČR
Projekt

Interactions of syncytins with specific cell receptors (GA17-14356S)

by interactions of syncytins and specific receptors on the cell surface. Syncytins 1 and 2 receptors (hASCT2/1, MFSD2) could be approached virologically by analyzing virus-cell fusion instead of cell-to-cell fusion. We plan to prep...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 7 524 tis. Kč
    • •
  • 6 717 tis. Kč
    • •
  • GA ČR
Projekt

Characterization of the cellular receptor Tvc and its role in the pathogenesis of avian leukosis viruses subgroup C-induced diseases (GA523/07/1282)

of the Tvc receptor in retroviral cythopathogenicity displayed in vitro. Furthermore discovered chicken cellular receptor (Tvc), a member of the butyrophilin superfamily entry into cells. We will attempt to identify the bi...

GG - Chov hospodářských zvířat

  • 2007 - 2009
    • •
  • 4 690 tis. Kč
    • •
  • 4 690 tis. Kč
    • •
  • GA ČR
Projekt

Dimerisation of retroviral proteinases characterisation, structure-activity and inhibition study (GA303/98/1559)

All retroviral proteins are expressed as polyprotein precursors. Specific of mature, infectious particles. Retroviral PRs are thus an attractive target for antiviral chemotherapy. All retroviral PRs are active as dimers. Th...

CE - Biochemie

  • 1998 - 2000
    • •
  • 2 878 tis. Kč
    • •
  • 2 643 tis. Kč
    • •
  • GA ČR
Projekt

Structure, function, substrate specificity and inhibition of retroviral proteinases protein engineering study of retroviral processing (IA455102)

CE - Biochemie

  • 1993 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Projekt

Fusogenic envelope glycoproteins of human endogenous retroviruses and their receptors (GA301/09/2031)

fusogenic envelopes with highly specific cell surface receptors, whose identity is unclear, with the exception of hASCT2, the cellular receptor for syncytin-1. Our project aims to the identification of new receptors for fu...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 715 tis. Kč
    • •
  • 3 715 tis. Kč
    • •
  • GA ČR
Projekt

The role of the ubiquitin and ubiquitin-like proteins in life cycle of the Mason-Pfizer monkey virus (GP301/06/P278)

for the forming of infective retroviral particles have been proved. Tha major aim of retroviral particle of Mason-Pfizer Monkey Virus (M-PMV). The goal is to find and transport of retroviral RNA, course of assembly and inf...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 1 167 tis. Kč
    • •
  • 1 167 tis. Kč
    • •
  • GA ČR
Projekt

The analysis of molecular organization of the retrovirus particle and interactions leading to its assembly (ME 904)

The aim is to employ a multi-methodical approach to study various aspects of formation of retroviral particles. This will be made possible by the employment of complementary highly specialized methods that are established exclusively interes...

EE - Mikrobiologie, virologie

  • 2007 - 2011
    • •
  • 2 391 tis. Kč
    • •
  • 2 391 tis. Kč
    • •
  • MŠMT
Projekt

Transcriptional silencing of retroviral vectors during their integration into the host genome (GP301/09/P667)

The transcriptional silencing of retroviral vectors represents major of silencing differs among retroviral vectors of different origin. ASLV-based vectors in gene therapy. Silencing of retroviral vectors is observed in two ...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
Projekt

Study of structure, function and inhibition of retroviral integrase and proteinase (IAA4055904)

, will be tested. For activation of retroviral proteolysis, we will express the proteinase (PR...

CE - Biochemie

  • 1999 - 2001
    • •
  • 8 099 tis. Kč
    • •
  • 1 959 tis. Kč
    • •
  • AV ČR
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