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8 (0,051s)

Projekt

Screening for hemochromatosis in blood donors. (IZ1913)

9F - 9

  • 1994 - 1995
  • 150 tis. Kč
  • 650 tis. Kč
  • MZ
Projekt

Diagnosis and detection of mutations in the COL4A5 gene in patients with Alpot syndrome. (IZ3783)

FG - Pediatrie

  • 1996 - 1998
  • 1 830 tis. Kč
  • 1 829 tis. Kč
  • MZ
Projekt

Project Immunological reactivity in patients with hereditary angioedema (NI5220)

The goal of the study is to determine increased risk of patients with hereditary angioedema for immunoregulatory disorders and their responsiveness on active immunization.......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
  • 1 540 tis. Kč
  • 1 540 tis. Kč
  • MZ
Projekt

Role of granulocytes and monocytes in induction and development of immunodeficiency disease and other immunopathological processes (NV15-28732A)

The project is focussed on monitoring the activation of granulocytes in patients with common variable immunodeficiency (CVID) and complement deficiency – hereditary angioedema (HAE). We will study the signs of granulocyte activation determined as pre...

EC - Imunologie

  • 2015 - 2018
  • 11 855 tis. Kč
  • 11 098 tis. Kč
  • MZ
Projekt

Genetic determination of bradykinin-mediated angioedema severity in patients with hereditary angioedema (NV18-05-00330)

Hereditary angioedema (HAE) is one of bradykinin-associated angioedema characterized by recurrent attacks of swelling. It is characterized by decreased level and/or function of C1 inhibitor (SERPING1), which results in local bradykinin overproduction...

Genetics and heredity (medical genetics to be 3)

  • 2018 - 2022
  • 12 026 tis. Kč
  • 11 869 tis. Kč
  • MZ
Projekt

Identification of genetic factors contributing to hereditary breast cancer development and prognosis (NV15-28830A)

Patients with hereditary breast cancer (BC) represent limited but highly important subgroup of patients suffering from high probability and early onset of BC development, increased risk of disease recurrence and development of other cancers and 50% r...

EB - Genetika a molekulární biologie

  • 2015 - 2018
  • 8 539 tis. Kč
  • 8 539 tis. Kč
  • MZ
Projekt

Intracellular expression of C1INH in leukocytes of patients with hereditary angioedema (NW25-05-00280)

Hereditary angioedema is a disease characterized by the sudden onset of swellings, caused by a reduced level of C1 inhibitor, which normally blocks the release of the vasodilatory molecule bradykinin. The C1 inhibitor is encoded by the SERPING1 gene ...

Immunology

  • 2025 - 2028
  • 14 359 tis. Kč
  • 14 359 tis. Kč
  • MZ
Projekt

The role of uPAR alternative isoforms in immunopathological response (NU21-05-00438)

PLAUR gene encodes the receptor for urokinase plasminogen activator uPAR (CD87), which is localized at the plasma membrane and acts as a multifunctional protein involved in several physiological processes. uPAR affects fibrinolysis following an inter...

Human genetics

  • 2021 - 2025
  • 11 921 tis. Kč
  • 11 921 tis. Kč
  • MZ
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