Filtry
Depletion of T regulatory cells without need of anti-CD25 mAb for effective chemoimmunotherapy by HPMA-based polymeric drugs and IL-2 immunocomplexes (GAP301/11/0325)
. However, anti-CD25 mAb can also eliminate subsequently activated T cells, includingT regulatory cells (Treg) are key players in inhibiting T cell mediating immune responses. It was shown in numerous tumor models ...
FD - Onkologie a hematologie
- 2011 - 2015 •
- 17 039 tis. Kč •
- 17 039 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Immunoregulatory functions in children with diabetes mellitus (NR9355)
This project deals with a possible supression of autoagressive T cell clones leading to the destruction of insulin producing beta cells by immunoregulatory CD4+CD25+ T cells in children with type 1 diabetes mellitu...
EC - Imunologie
- 2007 - 2009 •
- 10 398 tis. Kč •
- 10 386 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)
Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e. Treg and activated T cells. We participated in recent study which ultimately led. Moreover, it also allosterically lowers the affinity of IL-2 to ...
Immunology
- 2018 - 2022 •
- 4 804 tis. Kč •
- 4 762 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)
stimulatory activity for CD25+ cells and particularly for Treg cells. Treatment of mice with IL-2/JES6 leads to considerable expansion of Treg cells which are capable stimulate different subsets of immune cell...
EC - Imunologie
- 2013 - 2018 •
- 11 872 tis. Kč •
- 11 872 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 5. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)
+ T and NK cells, while those based on JES6-1A12 mAb (IL-2/JES6) stimulate selectively CD25+ cells, i.e. mostly Treg cells. Thus, the current paradigm in the field for different IL-2 responsive cells depen...
Oncology
- 2022 - 2024 •
- 8 330 tis. Kč •
- 8 330 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Significance of TACI mutations and lymphocyte subpopulations in pathogenesis of selective IgA deficiency (NS10398)
. These will include CD4+CD25+ cells, which can both be activated such as regulatory (Treg) lymphocytes. The number of Treg cells will be determined by a combination of CD4,CD25,CD127 antigens. CD21-CD38- B-cel...
EC - Imunologie
- 2009 - 2011 •
- 3 035 tis. Kč •
- 3 035 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The impact of DPP-4 inhibitor therapy on immunity functions in patients with type 2 diabetes mellitus (NT12407)
will be followed. In parallel, proportion of CD26 expressing cells within the CD4 and CD8 cells, together with the relevant enzymatic activity, Treg (CD4+CD25+CD127-/FoxP3+) and CD86+ monocytic cells and alternati...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2011 - 2015 •
- 6 646 tis. Kč •
- 6 630 tis. Kč •
- MZ
Řešení projektu: 1. 6. 2011 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Adjuvant and immunotherapeutic properties of Bordetella pertussis adenylate cyclase toxin (GP310/09/P582)
Dendritic cells (DC) represent potent antigen presenting cells crucial and modulate the ability of DC to prime antigen specific CD4+ and CD8+ T cells in respect regulatory cells by CyaA-treated DC shall be examined...
EC - Imunologie
- 2009 - 2011 •
- 2 049 tis. Kč •
- 2 049 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Monocyte subpopulations in kidney transplantation and regulatory mechanisms of human macrophage differentiation (NS10524)
schedule. The determination of T regulatory cells (CD4+CD25+Foxp3+) and gene cell line THP-1, the expression of CD14+CD16+ phenotype will be induced......
EC - Imunologie
- 2009 - 2011 •
- 4 206 tis. Kč •
- 4 206 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Development of peripheral gamma delta T lymhocytes in swine (GA524/07/0087)
of porcine gd T cells outside of thymus (so called peripheral gd T lymphocytes). Our+CD8aa+. (3) We also propose to test the hypothesis that CD25 molecule can further discriminate MHC-II+CD45RC+ gd T cells into actually ac...
EC - Imunologie
- 2007 - 2011 •
- 5 856 tis. Kč •
- 5 856 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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