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3 776 (0,076s) •

Projekt

Immunotherapy of MHC class I - Tumours Modulation of the MHC Class I Expression by Demethylation, Selection of Proper Adjuvants (GA301/04/0492)

response,which are dependent on the expression of MHC class I molecules on tumour cells, and to develop the anti-tumour immunotherapy. We will induce the expression of the MHC class I molecules o...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 979 tis. Kč
    • •
  • 2 979 tis. Kč
    • •
  • GA ČR
Projekt

Tumours of human papillomavirus origin with different expression of MHC class I molecules theoretical principles of immunotherapy. (NR7807)

In this grant project it will be investigated whether there is a lack of immunological cross-reactivity between MHC class I positive and MHC class I negative tumours supra-treshold levels of the <...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 4 218 tis. Kč
    • •
  • 2 404 tis. Kč
    • •
  • MZ
Projekt

Imunization against Tumors Characterized by Different Escape Mechanisms (NC7552)

Imunization against mouse tumor cells with reduced expression of MHC class I molecules and /or tumor antigen (oncoprotein E7 of human papillomavirus type 16). Utilization of DNA vaccines, cellular vaccines and reco...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 12 151 tis. Kč
    • •
  • 11 594 tis. Kč
    • •
  • MZ
Projekt

Role of NK, Th and tumour-infiltrating cells in chemotherapy and gene therapy of MHC I-defficient HPV 16-associated tumours (GA301/06/0774)

for combined therapy of tumours lacking MHC class I molecules. The experiments after.chemotherapy and gene therapy (expression of MHC class I molecules), to find out the most advantageous scheme ...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 2 760 tis. Kč
    • •
  • 2 760 tis. Kč
    • •
  • GA ČR
Projekt

Characterization of the ribosome translating pre-spliced mRNAs for the synthesis of antigenic peptide substrates for the MHC-I pathway (GA23-06884S)

The presentation of antigenic peptides (APs) on MHC-I molecules is essential that MHC-I APs are produced by a non-canonical mRNA translation event that is distinct data show that translation of pre-spliced...

Immunology

  • 2023 - 2025
    • •
  • 10 603 tis. Kč
    • •
  • 10 357 tis. Kč
    • •
  • GA ČR
Projekt

Non-replicative vectors for induction of specific cellular immune responses (GA310/01/0934)

A challenge in vaccine development is the design of efficient means for induction of cellular immune responses. While exogenous antigens are mainly presented on MHC class II molecules, endogenous viral, parasite and tumor <...

EC - Imunologie

  • 2001 - 2003
    • •
  • 4 552 tis. Kč
    • •
  • 3 632 tis. Kč
    • •
  • GA ČR
Projekt

Mechanisms of protective immunity against tumours with different expression of immunodulatory molecules (IAA500520807)

cells expressing the same oncoproteins E6/E7, but different in the expression of MHC class I and other immunomodulatory molecules, used as cellular vaccines against......

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 2 800 tis. Kč
    • •
  • 2 800 tis. Kč
    • •
  • AV ČR
Projekt

MHC class IIB genes of European cyprinid fish their genetic variability and evolution in relation to the host life-history traits and parasitism (GA524/04/1128)

. The aimsofthe project will be to investigate the allelic variability of MHC class IIB genesAnalyses of the major histocompatibility complex genes (MHC) have been part. The MHC presents a group of genes of the hig...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 451 tis. Kč
    • •
  • 2 951 tis. Kč
    • •
  • GA ČR
Projekt

Interaction of NK Potential Receptor NKR-P1 with MHC Class I Molecules - a Possible Role in NK Cell Recognition (GA310/94/1533)

9H - 9

  • 1994 - 1996
    • •
  • 830 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Projekt

Combined immunotherapy of tumors with different expression of MHC class I molecules (GA16-04477S)

This study will focus on the immunotherapy of tumors with reversibly or irreversibly down-regulated surface expression of MHC class I (MHC-I) molecules. In a mouse model of tumors associated with human pap...

EC - Imunologie

  • 2016 - 2020
    • •
  • 8 919 tis. Kč
    • •
  • 8 724 tis. Kč
    • •
  • GA ČR
  • 1 - 10 z 3 776