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Projekt

Cytokine/chemokine-mediated augmentation of intrinsic regeneration program and its activation in the neurons without connection to injured nerve (GA16-08508S)

-mentioned mediators will be tested in cervical ganglia neurons following sciatic nerve ganglia neurons without connection with injured nerve, is related with activation without connection with injured nerve by sig...

EC - Imunologie

  • 2016 - 2018
  • 6 692 tis. Kč
  • 6 616 tis. Kč
  • GA ČR
Projekt

Gene therapy of neuropathic pain and spasticity via subpial application of AAV vectors in area of spinal cord roots of sciatic nerve and spinal cord injury in minipigs (LTAUSA19029)

Understanding the molecular mechanisms of chronic neuropathic pain and muscle spasticity is hampered by the absence of suitable large animal preclinical models. Due to its size and comparable physiology with a man, the minipig represents a valuable m...

Neurosciences (including psychophysiology)

  • 2020 - 2023
  • 11 385 tis. Kč
  • 11 385 tis. Kč
  • MŠMT
Projekt

Changes of the satellite glial cells and their extracellular matrix after axotomy - conditions for the sympathetic sprouts in the spinal ganglia? (GA309/03/1199)

peripheral axotomy, root compression, and transection and compression of the sciatic nerve. We will search immunohistochemical changes in the satellite cells (e.g., GFAP......

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
  • 2 400 tis. Kč
  • 2 400 tis. Kč
  • GA ČR
Projekt

*Auto-injector prevention of nerve agent exposure. (FI-IM2/104)

*Auto-injector for prevention of nerve agent exposure and for mitigation their action for military and civilian persons....

CI - Průmyslová chemie a chemické inženýrství

  • 2005 - 2007
  • 37 731 tis. Kč
  • 12 530 tis. Kč
  • MPO
Projekt

Improvement and practical implementation of peripheral nerve decellularization technology for the purpose of developing a novel biological product - decellularized scaffold, for the allogeneic (TM01000031)

The aims of the project are: 1) Development and optimization of automated decellularization of human nerve tissue – utility model 2) The development of a new modern therapy product - Decellularized nerve allograft - functional sampl...

Health-related biotechnology

  • 2020 - 2023
  • 16 898 tis. Kč
  • 4 462 tis. Kč
  • TA ČR
Projekt

Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury (GA309/07/0121)

Peripheral nerve injury results in the peripheral neuropathic pain. However ganglia (DRG) induced by nerve injury are related with spontaneous ectopic activity nerve. It is assumed that cytokines play a key role for signali...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2009
  • 3 231 tis. Kč
  • 3 231 tis. Kč
  • GA ČR
Projekt

Novichok nerve agents - toxicity and countermeasures (GA22-12859S)

Weapons Convention, nerve agents still represent a permanent threat both in the military and civilian sector. A novichok is a group of nerve agents of the fourth generation, which differ in their scaffold from known nerve ...

Toxicology

  • 2022 - 2024
  • 8 793 tis. Kč
  • 8 793 tis. Kč
  • GA ČR
Projekt

Countermeasure against chemical terrorism - development of new antidotes against nerve agents (ME 865)

searching for the most spreaded pesticides as potentional nerve agents, test of ability to inhibite in vitro enzyme Acetylcholinesterase (AChE)......

CA - Anorganická chemie

  • 2006 - 2009
  • 1 668 tis. Kč
  • 1 668 tis. Kč
  • MŠMT
Projekt

Problems of the nerve fiber layer measurements for reviewering in aviation and clinical ophtalmology (MO66080398203)

The the establishment of new examination methods and procedures for better selection, check, assesing and erlier diagnostics for the flight population with the aim to improve the flight safety of the Czech Air Force personnel.......

FF - ORL, oftalmologie, stomatologie

  • 1998 - 2000
  • 2 050 tis. Kč
  • 2 050 tis. Kč
  • MO
Projekt

Robotized system for in vitro evaluation of novel rectivators of acetylcholinesterase inhibited by nerve agents (OVUOFVZ200801)

The aim of this project is to develop new robotic system based on sequential injection analysis (SIA) for testing of reactivation potency of newly synthesized antidotes against nerve agent poisonings.......

FP - Ostatní lékařské obory

  • 2008 - 2011
  • 3 704 tis. Kč
  • 1 460 tis. Kč
  • MO
  • 1 - 10 z 136