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1 452 (0,084s) •

Projekt

Role of L-arginine, methylarginines and their metabolism in regulation of endothelial homeostasis (GP13-40882P)

about role of L-arginine and methylarginines in the development of ednothelial dysfunction. Molecular mechanism of L-arginine and methylarginines metabolism will be evalueated on cellular (human endothelial cells....

ED - Fyziologie

  • 2013 - 2014
    • •
  • 1 618 tis. Kč
    • •
  • 1 618 tis. Kč
    • •
  • GA ČR
Projekt

The influence of L-arginine and its analogues on the generation of reactive oxygen and nitrogen species by professional phagocytes (GA524/08/1753)

The aim of the project is to determine the effects of L-arginine and its analogues on the activity of NADPH oxidase, myeloperoxidase and inducible nitric oxide synthase. The activity of enzymes will be analysed in: i) ?chemical? sys...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2008 - 2012
    • •
  • 4 969 tis. Kč
    • •
  • 4 969 tis. Kč
    • •
  • GA ČR
Projekt

Metabolic effect of L-arginine supplementation and ACE inhibitors in diabetes and renal insuficience. (IZ4201)

The effect of long-term administration of L-arginine, the substrate for nitric oxide synthesis, and ACE inhibitors on metabolic disorders, the function and anti-oxidative capacity of the heart will be investigated.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 2 122 tis. Kč
    • •
  • 1 539 tis. Kč
    • •
  • MZ
Projekt

NO and L-arginine metabolism after cadaver renal graft transplantation (NK4906)

L-arginine in CyA toxicity also in a rat model of the ischemic kidney simulating the state after Tx. And this even if initiating therapy with L-arginine after......

FE - Ostatní obory vnitřního lékařství

  • 1998 - 1999
    • •
  • 677 tis. Kč
    • •
  • 484 tis. Kč
    • •
  • MZ
Projekt

Evaluation of lateralisation of nitric oxide mediator system in the hippocampus of people with schizophrenia and Alzheimer disease (NF7576)

Expression and activity of nitric oxide synthases and concentrations of L-glutamate, L-arginine, L-citrulline, nitrites/nitrates will be determined in both hippocampi of people with schizophrenia, Alzheimer disease...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 5 364 tis. Kč
    • •
  • 5 257 tis. Kč
    • •
  • MZ
Projekt

Investigating the Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor using Computational Simulations (GA13-21053S)

. Arginine repressor (ArgR) is the master regulator of the arginine regulon in a wide of L-arg. Asymmetric allosteric activation of ArgR is an apparent paradox in view affinities create two action levels in the protein's re...

CF - Fyzikální chemie a teoretická chemie

  • 2013 - 2018
    • •
  • 3 883 tis. Kč
    • •
  • 3 883 tis. Kč
    • •
  • GA ČR
Projekt

Influence of tyrosine oxidation on structure of neurodegenerative proteins (GA17-00121S)

Structural changes of neurodegenerative proteins caused by oxidative stress will be investigated on chemical models by chiroptical spectroscopies combined with theoretical calculations of spectra. Some pathways of oxidative stress lead to various mo...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 5 864 tis. Kč
    • •
  • 5 669 tis. Kč
    • •
  • GA ČR
Projekt

Dietary and pharmacological modulation of SCD1 as a tool for studying the link between ectopic lipid storage and insulin sensitivity in obesity (GA17-11027S)

with polyunsaturated fatty acids (PUFA) of n-3 series (Omega-3), namely EPA and DHA, given was based on n-6 PUFA or saturated fatty acids (SFA); however, the effects on glucose) at different ambient temperatures, using die...

ED - Fyziologie

  • 2017 - 2021
    • •
  • 7 246 tis. Kč
    • •
  • 7 000 tis. Kč
    • •
  • GA ČR
Projekt

The role of intestine in differential metabolic effects of various lipid forms of dietary omega-3 fatty acids (GA16-08124S)

Polyunsaturated fatty acids of n-3 series (Omega-3), mainly EPA and DHA the mechanisms of Omega-3’s effects on lipid metabolism in the liver is relatively well also showed that metabolic effects are stronger when Omega<...

ED - Fyziologie

  • 2016 - 2020
    • •
  • 6 649 tis. Kč
    • •
  • 6 246 tis. Kč
    • •
  • GA ČR
Projekt

Screening of antibacterial and anti-inflammatory activity of selected species of genus Nigella L. (GA525/02/0257)

Project deals with determination of antibacterial, anti-inflammatory and immunomodulatory activities of selected species of the genus Nigella L. (mainly of species N. damascena L., N. arvensis L. and N...

GM - Potravinářství

  • 2002 - 2004
    • •
  • 2 044 tis. Kč
    • •
  • 1 684 tis. Kč
    • •
  • GA ČR
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