Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells
Cíle projektu
The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS?s new approach will involve a new generation of bio-functionalised multifunctional magnetic nanoand microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or ?micrometastases? andthe molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation, and a research-intensive SME for exploitation.
Klíčová slova
CTC - Circulating tumour cellDTC - Disseminated tumour cellMultidimensional Image AnalysisMicro-Electro-Mechanical SystemNanoparticlesAnalysis of cell markersBiofunctionalizationImmunoaffinity capturing
Veřejná podpora
Poskytovatel
Ministerstvo školství, mládeže a tělovýchovy
Program
Podpora projektů sedmého rámcového programu Evropského společenství pro výzkum, technologický rozvoj a demonstrace (2007 až 2013) podle zákona č. 171/2007 Sb.
Veřejná soutěž
FP7-NMP-2008-SMALL-2
Hlavní účastníci
—
Druh soutěže
RP - Spolufinancování programu EK
Číslo smlouvy
1088/2011-321
Alternativní jazyk
Název projektu anglicky
Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells
Anotace anglicky
The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS?s new approach will involve a new generation of bio-functionalised multifunctional magnetic nanoand microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or ?micrometastases? andthe molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation, and a research-intensive SME for exploitation.
Vědní obory
Kategorie VaV
ZV - Základní výzkum
CEP - hlavní obor
CE - Biochemie
CEP - vedlejší obor
EI - Biotechnologie a bionika
CEP - další vedlejší obor
FP - Ostatní lékařské obory
OECD FORD - odpovídající obory
(dle převodníku)10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
20801 - Environmental biotechnology
20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management
20803 - Environmental biotechnology related ethics
20901 - Industrial biotechnology
20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
30106 - Anatomy and morphology (plant science to be 1.6)
30107 - Medicinal chemistry
30108 - Toxicology
30109 - Pathology
30221 - Critical care medicine and Emergency medicine
30223 - Anaesthesiology
30224 - Radiology, nuclear medicine and medical imaging
30225 - Allergy
30226 - Rheumatology
30227 - Geriatrics and gerontology
30229 - Integrative and complementary medicine (alternative practice systems)
30230 - Other clinical medicine subjects
30307 - Nursing
30308 - Nutrition, Dietetics
30309 - Tropical medicine
30310 - Parasitology
30311 - Medical ethics
30312 - Substance abuse
30401 - Health-related biotechnology
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
30404 - Biomaterials (as related to medical implants, devices, sensors)
30405 - Medical biotechnology related ethics
30501 - Forensic science
30502 - Other medical science
40401 - Agricultural biotechnology and food biotechnology
40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming
40403 - Agricultural biotechnology related ethics
Hodnocení dokončeného projektu
Hodnocení poskytovatelem
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Zhodnocení výsledků projektu
Hodnocení výsledků řešení ministerstvo neprovádí, neboť podmínkou podpory je, že uchazeč byl vybrán mezinárodním poskytovatelem v souladu s pravidly příslušného programu. Projekt je hodnocen až po jeho schválení mezinárodním poskytovatelem.
Termíny řešení
Zahájení řešení
1. 8. 2009
Ukončení řešení
31. 7. 2012
Poslední stav řešení
U - Ukončený projekt
Poslední uvolnění podpory
18. 4. 2012
Dodání dat do CEP
Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP13-MSM-7E-U/01:1
Datum dodání záznamu
28. 6. 2013
Finance
Celkové uznané náklady
3 355 tis. Kč
Výše podpory ze státního rozpočtu
3 355 tis. Kč
Ostatní veřejné zdroje financování
0 tis. Kč
Neveřejné tuz. a zahr. zdroje finan.
0 tis. Kč
Základní informace
Uznané náklady
3 355 tis. Kč
Statní podpora
3 355 tis. Kč
100%
Poskytovatel
Ministerstvo školství, mládeže a tělovýchovy
CEP
CE - Biochemie
Doba řešení
01. 08. 2009 - 31. 07. 2012