Mechanismy imunomodulace po napadení hostitele ptačí neuropatogenní schistosomou Trichobilharzia regenti

Název projektu anglicky
Mechanisms of host immunomodulation by Trichobilharzia regenti, an avian neuropathogenic schistosome
Anotace anglicky
The project is aimed at immunomodulatory effects of a parasite and immune reactions of an accidental host (mouse); Trichobilharzia regenti as a neuropathogenic fluke will be used. Although T. regenti parasitizes birds as natural hosts, it also attacks mammals (including humans) as accidental hosts, causing not only cercarial dermatitis, but also damage to the nervous system (in experimental animals). A broad spectrum of immunological, proteomic/genomic, histological, biochemical and imaging techniques will be applied. Although general immune status of the infected hosts (innate and adaptive immunity) will be observed, mainly the phase after CNS attack by parasites will be in focus. Characterization of cellular and humoral immunological parameters will be enriched by the study of selected parasite proteins and glycans that may have antigenic/immunomodulatory effects. In addition, factors/markers (e.g., matrix metallopeptidases) linked with CNS damage will be identified. Immune reactions and pathogenesis will also be evaluated with regard to parasite number and location.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30303 - Infectious Diseases
OECD FORD - vedlejší obor
30102 - Immunology
OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EC - Imunologie<br>FN - Epidemiologie, infekční nemoci a klinická imunologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP21-GA0-GA-R/11:1
Datum dodání záznamu
22. 2. 2021

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