Protein p63 - objasnění jeho regulace a interakcí.

Název projektu anglicky
Unravelling the regulation and interactions of p63.
Anotace anglicky
p63 is a member of the p53 family but has distinct functions in normal development and cancer. Like p53, many of the transcriptional targets of p63 are known, but, unlike p53, how p63 is regulated at transcriptional/post-transcriptional levels is unclear. Similarly, unlike the myriad of post-translational modifications known on p53, these are largely unknown on p63, or their alterations under different physiological or stress conditions. Interacting partners of p63 are also largely unknown. This project will address these gaps in basic knowledge. Based on preliminary data, we will study the regulation of p63 protein and mRNA levels and stability under various growth and stress conditions. We will use state-of-the-art technologies to systematically identify post-translational modifications to p63 under these conditions and use proteomic approaches to identify stable and transient interactions of p63 with other proteins. The study will provide a basic understanding of how p63 is regulated in health and disease, with future potential for the development of therapeutic agents.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10601 - Cell biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP22-GA0-GA-R
Datum dodání záznamu
22. 2. 2022

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