Jaderná fáze polyomavirové infekce: restrikce a ustavení infekce.

Název projektu anglicky
Nuclear phase of polyomavirus infection: virus restriction and infection establishment.
Anotace anglicky
Proposed project is a continuation of research of polyomavirus (PyV) trafficking to the cell nucleus and sensing its genome by DNA sensors. It will be dedicated to unknown mechanisms of infection of model mouse PyV and human BKPyV in the cell nucleus - interactions with nuclear proteins positively or negatively affecting establishment of infection. Lamins and associated proteins participate on dynamic changes of nuclear structures and also e.g. on virus uncoating. The goal will be to reveal how viral proteins affect nuclear lamina and matrix. Early after PyV genomes enter the nucleus, they appear in the proximity of PML nuclear bodies (PML-NBs), where they are transcribed and replicated. At the beginning, PML-NBs repress PyV transcription. The assignment will be to search for restriction factors connected with PML-NBs and for mechanisms by which the virus overcomes restriction. In preliminary experiments, Sp100 or Sp110 proteins and also Smc5/6 complex, co-localising with PyV genome near PML-NBs and being degraded during PyV infection, were selected as candidates.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10607 - Virology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EE - Mikrobiologie, virologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GA-R
Datum dodání záznamu
26. 6. 2023

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