Antidepresiva v těhotenství; vliv na placentární transport a metabolismus serotoninu

Název projektu anglicky
Antidepressants in pregnancy; effect on placental transport and metabolism of serotonin
Anotace anglicky
Depression is a serious disabling illness affecting 7-25% of pregnant women; its prevalence has increased dramatically in recent years. Despite the risks associated with antidepressant drug (AD) use during pregnancy, an estimated 13% of pregnant women are prescribed ADs. Large-scale epidemiological studies have linked the prenatal use of ADs with disturbances in fetal development, including neurobehavioral disorders, pulmonary hypertension, cardiac and gastrointestinal toxicity. However, the molecular mechanisms of these toxic effects are poorly understood. Considering the fact that (i) current ADs target serotonin (5-HT) transport or metabolism and (ii) because of the diverse functions of 5-HT in various tissues (e.g. brain, intestine, lungs, heart, or platelets), it is feasible to assume that suboptimal 5-HT levels in utero could adversely affect fetal organ development and programming. As placenta plays a key role in regulating fetal 5-HT levels, we believe that disruption of 5-HT pathways in the feto-placental unit by ADs may, at least partly, explain their prenatal toxicity.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30104 - Pharmacology and pharmacy
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
FR - Farmakologie a lékárnická chemie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GA-R
Datum dodání záznamu
26. 6. 2023

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