Cesta tam a zase zpátky: funkce kyseliny fosfatidové v transportu proteinů do a z jádra rostlinných buněk

Název projektu anglicky
There and back again: the role of phosphatidic acid in the protein transport to and from the nucleus in plant cells
Anotace anglicky
The movement of proteins into and from the nucleus is a fundamental process critical to the basic function and regulation of eukaryotic cells. Recently, anionic phospholipid-protein interactions were proposed as one of the mechanisms controlling nuclear transport across eukaryotes. We have isolated several phosphatidic acid (PA)-binding proteins with nuclear-related function that shuttle between nucleus and distinct cellular compartments and play a role in the regulation of pollen germination and tube growth. We therefore hypothesize that in plants, multiple signalling and metabolic pathways converge on PA, which plays major role in the regulation of nuclear protein transport. We will employ methods of advanced microscopy, biochemistry and computational modelling and tobacco pollen tubes as excellent unicellular cell-biological system to test i) how distinct cellular pools of PA regulate the shuttling of specific effector proteins between nucleus, cytoplasm or membranes and ii) what is the role of PA-mediated binding of nuclear pore complex (NPC) proteins in the organization of NPC.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10601 - Cell biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GA-R
Datum dodání záznamu
26. 6. 2023

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