Kontrola vstupu do anafáze během časného vývoje

Název projektu anglicky
Control of anaphase entry during early development
Anotace anglicky
Anaphase Promoting Complex (APC/C) is a ubiquitin ligase activated after entry into mitosis or meiosis by CDC20 which targets multiple proteins for destruction during anaphase. The transition between metaphase and anaphase is thus unidirectional and the APC/C should be activated only after correct assembly of the spindle and attachment of all chromosomes. In our project we would like to focus on mechanisms of regulation of APC/C in meiosis and also during the first mitoses after fertilization. Namely we would like to study the relationship between the quantity of the Spindle Assembly Checkpoint (SAC) signal and the APC/C activity, whether the Separase controls APC/C activity and whether the levels of proteins important for APC/C regulation are affected by silencing of transcription during this part of development. We will use mouse and bovine oocytes and embryos, which will make our results more relevant to the human development. Our results will aid to our understanding of aneuploidy, which is frequently leading into termination of development or to severe developmental disorders.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10604 - Reproductive biology (medical aspects to be 3)
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
21. 5. 2024

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