Xeno-free enzymaticky degradovatelné polymerní materiály pro 4D biotisk

Název projektu anglicky
Xeno-free enzymatically degradable polymer materials for 4D bioprinting
Anotace anglicky
Current biology has opened new avenue in biotechnological R&D aimed at ex vivo building 3D structures that closely resemble tissues/organs of living organism. Despite of self-organizing capacity of cells, extracellular 3D support is still envisioned to promote establishment of proper tissue morphologies. 3D bioprinting is attractive option of how cells can be positioned into right locations and supported in their development. Advanced concept is so called 4D bioprinting, defined by materials capable of post-printing responsiveness to stimuli. The key limitation to this approach lays in suboptimal chemistry of biomaterials, not providing enough flexibility in mechanical properties, internal geometry, ligand capture and release, etc. Here we propose preparation of fully synthetic (xeno-free) highly tunable polymers based on polyamino acids. We will also elaborate and thoroughly evaluate protocols for 4D bioprinting using lung cells/tissues as a model. This is highly interdisciplinary project that can only be done when advanced chemistry is accompanied by state-of-the-art cell biology.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10404 - Polymer science
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CD - Makromolekulární chemie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
21. 5. 2024

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