Cirkadiánní hodiny v choroidním plexu a jejich citlivost k chronodisrupci a neurozánětu

Název projektu anglicky
Circadian clock in choroid plexus and its sensitivity to chronodisruption and neuroinflammation
Anotace anglicky
Environmental and lifestyle-related factors may negatively affect brain function via chronodisruption, that is, impairment of circadian regulation, potentially accompanied by neuroinflammation. Choroid plexus (CP) harbors a robust circadian clock which might be involved in rhythmic production of cerebrospinal fluid and thus substantially influence the brain functioning. The knowledge on entrainment of the CP clock and its sensitivity to chronodisruption and challenged immune state are completely lacking. Therefore, using a genetically engineered mouse model with selective CP clock disruption, and mPer2Luc mouse for real-time bioluminescence recording and behavioral monitoring, we shall ascertain the role of the circadian clock in the CP function and coordination of other brain clocks, and the impact of chronodisruption and/or induced pro-inflammatory state on the selected brain clocks. The results will provide innovative insight into organization of the circadian clocks in the brain and may facilitate development of novel therapeutic approaches to treat neuropsychiatric disorders.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30105 - Physiology (including cytology)
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
ED - Fyziologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GA-R
Datum dodání záznamu
12. 3. 2025

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