Ciliární Tau tubulin kináza 2 ve zdraví a nemoci: struktura a funkce

Název projektu anglicky
Cilia-related Tau tubulin kinase 2 in health and disease: structure and function
Anotace anglicky
Tau tubulin kinase 2 (TTBK2) has emerged as a crucial regulator of primary cilia, sensory organelles with fundamental roles in both development and disease. However, the full understanding of what this kinase does (on the molecular level) that makes is it indispensable for cilia formation, and in turn, leads to pathologies, is lacking. Here we propose a research plan centered on the elucidation of the molecular mechanisms and functional consequences of TTBK2-related activities in primary cilia. The proposed project combines several state-of-the-art methodologies (advanced microscopy, proteomics, etc.) into both unbiased and hypothesis-driven experimental strategies, with the ambition to address important gaps in our understanding of the function, molecular mechanism, and upstream regulation of TTBK2 in cilia. We are convinced the project has the potential to significantly advance our understanding of the precise role of this kinase in the control of different aspects of cilia biology in health and disease.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10601 - Cell biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
19. 2. 2024

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