Neuroinflamace jako podklad vzniku bolesti

Název projektu anglicky
Neuroinflammation in development of pain
Anotace anglicky
Chronic painful conditions, especially of neuropathic origin are serious diseases that significantly limit patients by attacks of spontaneous pain and pain caused by innocuous stimuli. Current treatments are ineffective and with serious side effects. In order to develop new effective treatments, there is a great need to understand the pathophysiological mechanisms involved in their development. The aim of this project is to study the mechanisms of synaptic modulation at the spinal cord level that underlie the development of pathological pain conditions. The main focus will be on the role of neuroinflammation, chemokines (CXCL16) and cytokines (MIF) in modulating nociceptive information in the spinal cord, under control and pathological conditions. Our preliminary results show their important influence on the development of neuropathic pain and the possibility of its attenuation. The results will thus also point to new potential targets for the development of new treatments for neuropathic pain conditions. Electrophysiological, behavioural and immunohistochemical methods will be used.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30103 - Neurosciences (including psychophysiology)
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
FH - Neurologie, neurochirurgie, neurovědy

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
21. 2. 2024

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