Vodivé (bio)polymerní kompozity s kovalentně vázaným polypyrrolem pro biomedicínské aplikace

Název projektu anglicky
Conductive (bio)polymer composites with covalently anchored polypyrrole for biomedical applications
Anotace anglicky
Current polypyrrole (PPy) composites feature PPy attached to the supporting matrix only by weak interactions, resulting in the poor stability of the PPy layer and leaching of PPy particles, or covalently, which requires toxic solvents, linkers, and reactants. Here, a new, facile, and more environmentally friendly method for Dialdehyde Polysaccharide (DAP)-based covalent anchoring of PPy is proposed. Based on spontaneous aldol condensation between carbonyl groups of DAPs and pyrrole, tethering of PPy particles no longer requires toxic substances and complex organic chemistry. Combined with the ability of DAPs to simultaneously crosslink various matrices, this straightforward method elegantly merging different DAP chemistries is used to localize and harness the recently discovered immunomodulatory and antioxidative activity of PPy into various conductive anti-inflammatory composite biomaterials for wound healing, from nanofiber patches to stimuli-responsive hydrogels. Besides the development of composites, the in vitro screening of their biomedical potential will be performed.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
OECD FORD - vedlejší obor
20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)
OECD FORD - další vedlejší obor
30404 - Biomaterials (as related to medical implants, devices, sensors)
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EI - Biotechnologie a bionika<br>JI - Kompositní materiály

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GA-R
Datum dodání záznamu
21. 2. 2025

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