Nukleoproteinové komplexy v DNA transpozičním mechanismu copy-out-paste-in

Název projektu anglicky
Nucleoprotein complexes in copy-out-paste-in DNA transposition
Anotace anglicky
DNA transposition is one of the main pathways for DNA mobilization, which contributes to the emergence of antibiotic resistance, a pressing medical issue worldwide. Although it is well understood on a genetic level, it often remains elusive on a molecular level, even in clinically significant cases. Understanding the different transposition mechanisms on a molecular level is crucial for identifying novel approaches to modulate the emergence of antibiotic resistance. Here, we focus on mechanism copy-out-paste-in, a major bacterial transposition pathway, that has been shown to be one of the most impactful and is mechanistically diverse from others due to its multistep process of DNA mobilization. This process is characterized by the excision of the element in circular DNA intermediate and its subsequent integration. The project aims to identify and characterize differences in the composition of nucleoprotein complexes formed during the transposition pathway. It seeks to understand their structural organization and functional aspects that result in different reaction outcomes.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10608 - Biochemistry and molecular biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CE - Biochemie<br>EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GA-R
Datum dodání záznamu
21. 2. 2025

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