Buněčná podstata hojení zubu

Název projektu anglicky
Cellular Basis of Dental Healing
Anotace anglicky
Teeth are living structures that can actively respond to their own damage. There are several ways how teeth can heal and thus naturally prolong their functionality and lifespan. Although the reparative capabilities of the tooth are well known, the processes behind them are far from being understood. This project will comprehensively investigate the principles of tooth healing, from damage detection, through cellular and molecular responses, to the study of microstructure of the resulting newly formed hard tissues inside the tooth. To achieve this, a combination of state-of-the-art approaches was proposed. These include our newly developed method for monitoring hard tissue growth dynamics in time and space (BEE-ST), single-cell RNA-sequencing, lineage tracing, reporter mouse strains, and advanced microscopic techniques. The project is based on extensive preliminary data and previous experience of the team, supported by recent publications. The results will provide new insights into mechanisms of the healing process, which will help to accelerate the advent of regenerative dentistry.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10605 - Developmental biology
OECD FORD - vedlejší obor
30106 - Anatomy and morphology (plant science to be 1.6)
OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EB - Genetika a molekulární biologie<br>FP - Ostatní lékařské obory

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GA-R
Datum dodání záznamu
28. 2. 2025

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