RAD60 - a new player in the maintenance of genome stability in plants

Název projektu anglicky
RAD60 - a new player in the maintenance of genome stability in plants
Anotace anglicky
Genome stability is maintained via a network of DNA damage response (DDR) proteins orchestrated by specific signal molecules and post-translational modifications. The attachment of a Small Ubiquitin-like Modifier (SUMO) protein to the target proteins is essential for DDR signaling. Here, we propose a project focusing on the functional characterization of a newly discovered plant homolog of the RENi family protein RAD60. RENi proteins contain tandemly organized SUMO-like domains and, in conjunction with interacting proteins, stimulate SUMOylation during DDR. Interestingly, plant RAD60 has only a single SUMO-like domain and a unique N-terminus. In this project, we will cooperatively (i) anchor the Arabidopsis RAD60 in the plant DDR pathways, (ii) study its role in preventing genome instability, (iii) identify its interaction partners, and (iv) characterize its stimulatory effect on SUMOylation of plant DDR factors. The results of this project will greatly improve the functional understanding of the role of SUMOylation in the plant DDR.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10611 - Plant sciences, botany
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EF - Botanika

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GA-R
Datum dodání záznamu
1. 6. 2026

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