Nanoparticles Based on New Polymers of Bioanalogous Phenols as a Potential Platform for Intranasal Delivery

Název projektu anglicky
Nanoparticles Based on New Polymers of Bioanalogous Phenols as a Potential Platform for Intranasal Delivery
Anotace anglicky
Intranasal administration of active substances is a non-invasive way to achieve a rapid onset of action at both systemic and organ-specific levels. Substances able to penetrate the nasal mucosa may rapidly and directly enter the bloodstream, the lymphatic system, or directly to the brain. A key feature of this administration is the avoidance of the first-pass effect. Nanoparticulate formulations can mediate such transport of substances that do not have this ability per se. The aim of the project is to develop novel nanoparticle systems based on polymers of bio-phenols analogous to neurotransmitters of tyramine series, which are able to penetrate the internal environment of the organism through the nose cavity. The composition of particle matrix and their surface properties will be investigated in relation to their toxicity, mechanism of penetration, and behaviour in biological systems. Biodistribution of the nanoparticles will be studied in biological models by imaging techniques in vivo.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10404 - Polymer science
OECD FORD - vedlejší obor
30404 - Biomaterials (as related to medical implants, devices, sensors)
OECD FORD - další vedlejší obor
21001 - Nano-materials (production and properties)
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CD - Makromolekulární chemie<br>EI - Biotechnologie a bionika<br>JJ - Ostatní materiály

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GA-R
Datum dodání záznamu
19. 5. 2026

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