Metabolomics-driven discovery of plant chemical novelty and its insecticidal potential

Název projektu anglicky
Metabolomics-driven discovery of plant chemical novelty and its insecticidal potential
Anotace anglicky
In this proposal, we will develop an integrative pipeline for high-throughput discovery of structurally novel natural products from plants and assess their insecticidal potential against polyphagous insects. We will combine phylogenomics and automated literature mining to prioritize and select understudied plant lineages for phytochemical investigation. We will profile the metabolite content of the selected plant species using mass spectrometry-based metabolomics, and analyze the resulting data using state-of-the-art computational tools. Using a cheminformatics approach recently developed in our lab, we will select 50 plant extracts with the highest structural novelty potential and screen them for insecticidal activity against a panel of 5 polyphagous insect species. This screening will: i) lead to the discovery of structurally-novel phytochemicals with insecticidal potential; ii) generate a large dataset of plant-insect interactions linked to their chemical profiles. This data will constitute a valuable resource for other disciplines (e.g., entomology, chemical ecology).

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10611 - Plant sciences, botany
OECD FORD - vedlejší obor
10619 - Biodiversity conservation
OECD FORD - další vedlejší obor
10609 - Biochemical research methods
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CE - Biochemie<br>EB - Genetika a molekulární biologie<br>EF - Botanika<br>EH - Ekologie – společenstva

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GA-R
Datum dodání záznamu
30. 4. 2026

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