A neurobiological model of paraphilic development in the male rat

Název projektu anglicky
A neurobiological model of paraphilic development in the male rat
Anotace anglicky
Theories of the development of paraphilias in humans posit predisposing genetic and/or personality traits, and/or early sexual experience with paraphilic behaviors that are predictive of sexual arousal and/or orgasm. It is impossible to know conclusively what type or amount of experience during early sexual development leads to paraphilic interests, and what kind of brain activation sustains those interests into adulthood. The proposed studies will examine the development of paraphilic-like preferences for neutral or aversive odors, or neutral somatosensory stimuli that are paired with orgasm-like responses in male rats. We have shown that the opioid receptor antagonist naloxone and the lysine-specific demethylase inhibitor oryzin can block conditioning, indicating that opioid-induced epigenetic changes are important for its development. We will extend these findings to examine common brain regions activated by the conditioned stimuli, and within those regions, to examine demethylated and methylated states of genes with either excitatory or inhibitory actions on sexual behavior.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30301 - Social biomedical sciences (includes family planning, sexual health, psycho-oncology, political and social effects of biomedical research)
OECD FORD - vedlejší obor
30103 - Neurosciences (including psychophysiology)
OECD FORD - další vedlejší obor
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EI - Biotechnologie a bionika<br>FH - Neurologie, neurochirurgie, neurovědy<br>FL - Psychiatrie, sexuologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GA-R
Datum dodání záznamu
19. 5. 2026

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