Targeting of somatic hypermutation by the interplay of transcriptional kinetics and DNA repair fidelity

Název projektu anglicky
Targeting of somatic hypermutation by the interplay of transcriptional kinetics and DNA repair fidelity
Anotace anglicky
Somatic hypermutation (SHM) is a key process in diversification of antibodies. This process is initiated by cytosine deamination by the activation-induced cytidine deaminase (AID) and completed by error-prone processing of the resulting uracils. Although SHM aims primarily to Ig loci, frequent targeting of non-Ig loci has been reported, accentuating the role of SHM in lymphomagenesis. We developed a series of novel methods providing data on SHM susceptibility in the B cell genome and identifying a series of factors involved in SHM. Based on our preliminary results, we propose a model of SHM targeting that combines the roles of AID access to various genomic regions and site-specific variability of error-proneness of DNA repair. Our novel approach will decipher the transcriptional kinetic features involved in targeting of AID activity and identify factors responsible for specific distribution of cytidine deamination and high error rate of DNA repair in SHM-targeted regions. Our study will provide a novel insight into the mechanism of SHM targeting and its involvement in lymphomagenesis

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30102 - Immunology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EC - Imunologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GA-R
Datum dodání záznamu
27. 4. 2026

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