FasL v osteogenezi, zdraví a nemoci parodontu

Název projektu anglicky
FasL in osteogenesis, periodontal health and disease
Anotace anglicky
FasL/Fas system was identified in apoptotic elimination of cells, however, there is an emerging evidence about non-apoptotic FasL functions. Recently, sclerostin (Sost) expression was found to be decreased in the mandibular bone of FasL deficient mice by the Czech Team thereby suggesting a novel non-apoptotic function of FasL. Consequently, Sost tooth/periodontium phenotype was published by the Austria Team. The overall research aims of this joint project are: (i) To experimentally confirm Sost expression modulation by FasL, (ii) to experimentally challenge possible reciprocal interactions between FasL and Sost, (iii) to decipher the molecular mechanism(s) behind FasL and Sost interactions, (iv) to characterize the dental and periodontal phenotype of FasL knockout mice, (v) to study healing of extraction sockets in FasL knockout mice, (vi) to investigate the role of FasL in regulation of lipopolysaccharide (LPS)-induced periodontitis in mice. The main focus is basic research, which however would provide data interesting for regenerative dentistry and clinical applications.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10601 - Cell biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP22-GA0-GF-R
Datum dodání záznamu
21. 2. 2022

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