Lekce antikodonového kmene tRNA z pročítání stop kodónu.

Název projektu anglicky
Stop codon readthrough lessons from the tRNA anti-codon stem.
Anotace anglicky
If you imagine a gene as a sentence starting with a capital letter and ending with a period, and a genome as a book telling an entire story, it has recently been shown that specific organisms exist where extra periods infiltrated their sentences. As a result, readers (in this case ribosomes) are confused as to where these sentences really end and the story becomes disjointed. We have discovered a molecular mechanism that these organisms developed to allow the reader/ribosomes to go through their sentences as if there were no extra periods. The sentences are so specifically encrypted that readers/ribosomes of no other organisms but those very few can decipher the story in a proper way. The trick is in the nature and length of the anticodon stem of readthrough-inducing tRNAs and mutant release factors. We have also seen these tricks to be employed in programmed stop codon readthrough in all organisms. Here, in the three-party collaboration, we will subject these critical players to an in-depth analysis and attempt to solve the structure of an 80S ribosome reading through a stop codon.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10606 - Microbiology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EE - Mikrobiologie, virologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GF-R
Datum dodání záznamu
4. 9. 2023

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